Objectives: Maternal nutritional deficiency is an important predisposing factor to congenital neural tube defects (NTDs). It was hypothesized that obese women may have an increased risk for NTDs. The aim of the present study was to address this question in a large cohort. Methods: A total of 72,915 consecutive cases of biochemical screening that had documented maternal weights and pregnancy outcomes were identified from the Quest Diagnostic Laboratories database. Patients were divided into five ranges of maternal weights, and the incidence of NTDs was calculated for each group. Based on the different definitions of maternal overweight, the data were also analyzed based on 2 groups only, obese and nonobese, using three cutoff points. Results: Seventy-nine pregnancies were complicated by NTDs (incidence of 1.08 per 1,000 pregnancies). Differences between maternal weights ranges were not found to be statistically significant (χ2 = 5.997, p = 0.19, power = 0.99). Differences between obese and nonobese mothers were not found to be statistically significant for all three analyses as well. Conclusions: Our present results do not support an association between maternal obesity and NTDs.
Mark I. Evans, MD
Division of Reproductive Genetics
Department of Obstetrics and Gynecology, Hutzel Hospital
4707 St. Antoine Boulevard, Detroit, MI 48201 (USA)
Tel. +1 313 745 7066, Fax +1 313 993 0153, E-Mail firstname.lastname@example.org
Received: Received: December 1, 1998
Accepted: February 5, 1999
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 4, Number of References : 25
Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)
Formerly ‘Fetal Therapy’
Official Organ of the ‘International Fetal Medicine, Surgery Society’ and the International Society ‘Fetus as a Patient’
Vol. 14, No. 3, Year 1999 (Cover Date: May-June 1999)
Journal Editor: W. Holzgreve, Basel
ISSN: 1015–3837 (print), 1421–9964 (Online)
For additional information: http://www.karger.com/journals/fdt
Article / Publication Details
Published online: 6/11/1999
Issue release date: May–June 1999
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4
ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)
For additional information: http://www.karger.com/FDT
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