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Vol. 82, No. 3, 2009
Issue release date: May 2009
Section title: Original Paper
Urol Int 2009;82:312–317
(DOI:10.1159/000209364)

Aurora-A/STK-15 Is Differentially Expressed in the Micropapillary Variant of Bladder Cancer

Compérat E. · Roupret M. · Conort P. · Chartier-Kastler E. · Bitker M.-O. · Richard F. · Capron F. · Haertig A. · Cussenot O. · Camparo P.
aService d’Anatomie et Cytologie Pathologique, Hôpital La Pitié Salpêtrière, and bService d’Urologie, Hôpital La Pitié Salpêtrière et Hôpital Tenon, CHU-Est, Université Pierre et Marie Curie, and cService d’Anatomie et Cytologie Pathologique, Hôpital des Instructions des Armées Val-de-Grâce, Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/11/2008
Accepted: 11/4/2008
Published online: 5/11/2009

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: Micropapillary carcinoma (MPC) of the bladder is a rare and aggressive histologic variant of urothelial carcinoma (UC). At the time of presentation, most MPC are muscle invasive with frequent vascular invasion (VI). Our series explores protein expression of markers known to be indicators of poor clinical outcome and progression, trying to explain aggressiveness of MPC. Patients and Methods: 18 patients with MPC were reviewed. We explored protein expression of p53, MIB-1, Aurora-A and survivin in MPC and compared their expression to conventional urothelial carcinoma (CUC) of the same grade and stage. Results: Patients, aged 46–85 years, underwent transurethral resection or cystoprostatectomy for UC. MPC was either pure (39%) or only partially present (61%). 55% of the patients died. VI was seen in 95%. MPC displayed overexpression of p53 and MIB-1, Aurora-A and survivin. No statistically significant difference could be made with CUC except for Aurora-A (p = 0.03). Conclusions: This is the first study to explore different markers of bad clinical outcome in MPC. We suggest that Aurora-A via mechanisms implied into early steps of mitosis might play a role in aggressive clinical behavior of MPC.


  

Author Contacts

Dr. Eva Compérat
Laboratoire d’Anatomie et Cytologie Pathologique, Hôpital La Pitié Salpêtrière
83, Bd de l’Hôpital
FR–75013 Paris (France)
Tel. +33 142 177 788, Fax +33 142 177 777, E-Mail ecomperat@yahoo.fr

  

Article Information

Received: July 11, 2008
Accepted: November 4, 2008
Published online: May 11, 2009
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 4, Number of References : 20

  

Publication Details

Urologia Internationalis

Vol. 82, No. 3, Year 2009 (Cover Date: May 2009)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/11/2008
Accepted: 11/4/2008
Published online: 5/11/2009

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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