Cover

The Menopausal Transition

Interface between Gynecology and Psychiatry

Editor(s): Soares C.N. (Hamilton, Ont.) 
Warren M. (New York, N.Y.) 
Table of Contents
Vol. 175, No. , 2009
Section title: Paper
Soares CN, Warren M (eds): The Menopausal Transition. Interface between Gynecology and Psychiatry. Key Issues in Mental Health. Basel, Karger, 2009, vol 175, pp 115–126
(DOI:10.1159/000209606)
Paper

Psychotic Disorders and Menopause: The Untold Story

Riecher-Rössler A.
Psychiatric Outpatient Department, University Hospital Basel, Basel, Switzerland

Abstract

This chapter aims to give an overview on the influence of menopause on psychotic disorders.Menopause is associated with a loss of estrogens; estrogen has important neuro- and psychoprotec-tive activities, thus its decline and/or instability may trigger or aggravate mental disorders includingpsychotic ones. As a result, perimenopause may lead to an enhanced risk of first onset of schizophrenic psychoses or ‘late-onset schizophrenia’. Women with pre-existing chronic schizophreniatend to have a deterioration of their illness after menopause and a higher demand for antipsychoticmedication. Apart from the psychotic symptoms, many other conditions can be aggravated by theloss of estrogens, including sleep disturbances, irritability, depression, cognitive impairment andsexual problems. In addition, many females with diagnosis of schizophrenia may present with premature menopause due to antipsychotic or stress-induced hyperprolactinamia and the subsequentgonadal suppression. Apart from psychotherapy and social measures, replacement of 17β-estradiolmay be helpful in women with schizophrenia in the perimenopause and early postmenopause, butits use might also carry some risks. More research is needed on the indications and contraindicationsfor hormone replacement in this context.

 goto top of outline Author Contacts

Prof. Dr. med. Anita Riecher, Psychiatric Outpatient Department, University Hospital Basel, Petersgraben 4, CH-4031 Basel (Switzerland), Tel. +41 61 265 51 14, Fax +41 61 265 45 99, E-Mail ariecher@uhbs.ch


 goto top of outline Article Information

Number of Print Pages : 12


 goto top of outline Publication Details

Book Serie: Key Issues in Mental Health, Vol. 175, Year 2009

Editor(s): Riecher-Rössler, A. (Basel); Steiner, M. (Hamilton, Ont.)
ISSN: 1662-4874 (Print), eISSN: 1662-4882 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1662-4874

Book Title: The Menopausal Transition (Interface between Gynecology and Psychiatry)

Editor(s): Soares CN, Warren M (eds)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1662-4874&volume=175


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.