Journal Mobile Options
Table of Contents
Vol. 13, No. 1, 2010
Issue release date: September 2009
Section title: Original Paper
Public Health Genomics 2010;13:13–20
(DOI:10.1159/000209879)

Family History as a Risk Factor for Early-Onset Stroke/Transient Ischemic Attack among Adults in the United States

Mvundura M. · McGruder H. · Khoury M.J. · Valdez R. · Yoon P.W.
aOffice of Public Health Genomics and bDivision for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, Ga., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/7/2008
Accepted: 1/20/2009
Published online: 3/23/2009

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG

Abstract

Background: Stroke is a major cause of morbidity and death in the United States. We tested the association between familial risk for stroke and prevalence of the disease among US adults and assessed the use of family history of stroke as a risk assessment tool for the disease. Methods: Using data from the 2005 HealthStyles survey (n = 4,819), we explored the association between familial stroke risk (stratified as high, moderate or low) and the prevalence of stroke and related health conditions. We evaluated the clinical validity (sensitivity, specificity) of family history of stroke as an indicator of stroke risk. Stroke and the related medical conditions were self-reported. Results: Independent of other risk factors, people with a high familial risk for stroke were 4 times more likely to have had a stroke (95% confidence interval, CI, 2.6–6.0) than people with moderate or low familial risk. They were also 1.3 times (95% CI 1.1–1.6) more likely to have high blood pressure and 1.5 times (95% CI 1.3–2.0) more likely to have congestive heart failure. The sensitivity and specificity of using family history alone, high blood pressure alone or both risk factors to estimate stroke risk were 52 and 83%, 53 and 74%, and 29 and 95%, respectively. Conclusions: Despite several limitations typical of self-reported surveys, we find that in this sample of US adults, family history of stroke was significantly associated with the risk for stroke and high blood pressure as well as related conditions. Family history of stroke, alone or combined with other risk factors, can be a useful tool in assessing stroke risk among US adults.


  

Author Contacts

Mercy Mvundura, PhD
National Office of Public Health Genomics
Centers for Disease Control and Prevention
4770 Buford Hwy, NE, Mailstop K – 89, Atlanta, GA 30341 (USA)
Tel. +1 360 236 3511, Fax +1 360 236 2323, E-Mail MMvundura@cdc.gov

  

Article Information

The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC.

Received: August 7, 2008
Accepted after revision: January 20, 2009
Published online: March 23, 2009
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 31

  

Publication Details

Public Health Genomics

Vol. 13, No. 1, Year 2010 (Cover Date: September 2009)

Journal Editor: Knoppers B.M. (Montreal, Que.), Brand A. (Maastricht), Burke W. (Seattle, Wash.), Khoury M.J. (Atlanta, Ga.)
ISSN: 1662-4246 (Print), eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/7/2008
Accepted: 1/20/2009
Published online: 3/23/2009

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.