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Original Article

Effects of Progesterone and Its Antagonist Mifepristone on Progesterone Receptor A Expression in Human Umbilical Vein Endothelial Cells

Toth B.a · Scholz C.b · Ochsenkühn R.a · Schulze S.b · Kuhn C.b · Friese K.a, b · Jeschke U.b

Author affiliations

aDepartment of Obstetrics and Gynecology, Grosshadern, bDepartment of Obstetrics and Gynecology, Innenstadt, Ludwig Maximilians University, Munich, Germany

Related Articles for ""

Gynecol Obstet Invest 2009;67:269–274

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: August 07, 2008
Accepted: December 09, 2008
Published online: April 01, 2009
Issue release date: May 2009

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Effects of female steroid hormones on endothelial cells are gaining increased importance due to several studies on the effects of hormonal treatment on cardiovascular risk. Recent data argue for an improvement of endothelium-derived relaxation and impaired vascular contraction by estradiol, whereas progesterone and testosterone might entail contrary effects. So far, gestagenic influence on endothelial cell physiology is poorly understood. Human umbilical vein endothelial cells (HUVECs) exposed to the female sex hormones estradiol and progesterone show expression of estrogen receptor-β (ERβ) and progesterone receptor A (PR-A), and are negative for ERα and PR-B. The aim of this study was to analyze the expression and stimulation of PR-A and -B in HUVECs after stimulation with progesterone and PR antagonists that are commercially available. PR-B expression or upregulation was abrogated after application of progesterone or antagonists to HUVECs. Expression of PR-A could be significantly upregulated with progesterone and mifepristone. Unexpectedly, stimulation with the progesterone antagonist RU486 (mifepristone) was accomplished by an upregulation of PR-A expression in our study. We conclude that gestagenic effects on HUVECs independent of modulators are mediated via the PR-A.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: August 07, 2008
Accepted: December 09, 2008
Published online: April 01, 2009
Issue release date: May 2009

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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