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Vol. 4, Suppl. 1, 1991
Issue release date: 1991
Section title: Immunopharmacology and Carcinogenesis
Skin Pharmacol 1991;4:64–70
(DOI:10.1159/000210984)

Histamine-Releasing Autoantibodies in Chronic Urticaria

Grattan C.E.H.
Institute of Dermatology, St. Thomas’s Hospital, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Immunopharmacology and Carcinogenesis

Published online: 3/31/2009
Issue release date: 1991

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Circulating histamine-releasing factors have been identified in the serum and plasma of chronic-urticaria patients by in vivo skin testing and in vitro histamine release from heterologous mixed leukocytes. Quantitative mast cell studies of serum skin test biopsies and electron microscopy indicate that the serum factors release histamine by mast cell degranulation. Peripheral blood basophils and total cellular blood histamine are reduced in chronic-urticaria patients suggesting that the circulating serum factors cause sustained degranulation. Histamine-releasing activity has been identified by skin testing in ultrafiltered serum fractions < 30 kDa and > 100 kDa. In vitro histamine-releasing activity was confined to ultrafiltered serum fractions > 100 kDa and was present in IgG purified from some chronicurticaria sera by protein G affinity chromatography. The dose-response relationship and kinetics of histamine release in vitro were similar to those of anti-human IgE. ‘Desensitisation’ of basophils by prior incubation with anti-IgE in the absence of calcium and competitive inhibition studies with myeloma IgE serum indicated that histamine-releasing autoantibodies in chronic-urticaria sera and purified IgG have the properties of anti-IgE. Plasma exchange in 4 patients with active chronic urticaria refractory to antihistamine therapy showing in vivo and in vitro histamine-releasing activity was followed by temporary remission of disease activity in 2 of them. It is possible that chronic urticaria is an autoimmune disease.

© 1991 S. Karger AG, Basel


  

Author Contacts

C.E.H. Grattan, Dermatology Office, Norfolk and Norwich Hospital, Brunswick Road, Norwich NR1 3SR (UK)

  

Article Information

Published online: March 31, 2009
Number of Print Pages : 7

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 4, No. Suppl. 1, Year 1991 (Cover Date: 1991)

Journal Editor: Lademann J. (Berlin)
ISSN: 1660-5527 (Print), eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Immunopharmacology and Carcinogenesis

Published online: 3/31/2009
Issue release date: 1991

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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