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Table of Contents
Vol. 7, No. 4, 1994
Issue release date: 1994
Section title: Original Research Article
Skin Pharmacol 1994;7:231–236
(DOI:10.1159/000211299)

Comparison of the Effects of Calcipotriol, Prednicarbate and Clobetasol 17-Propionate on Normal Skin Assessed by Ultrasound Measurement of Skin Thickness

Lévy J.a · Gassmüller J.a · Schröder G.b · Audring H.c · Sönnichsen N.c
aHumanpharmacology/ Dermatology and bPharma Deutschland/ Dermatology, Schering AG, cDepartment of Dermatology, Charité, Humboldt-University, Berlin, FRG

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 1/11/1993
Accepted: 3/19/1993
Published online: 3/31/2009
Issue release date: 1994

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

In this study, we investigated the effect of calcipotriol, prednicarbate and clobetasol 17-propionate on skin thickness over a treatment period of 6 weeks. The study was conducted as a controlled, randomized, double-blind comparison. The influence of these drugs on normal skin under occlusive conditions was assessed visually and by measuring skin thickness using 20 MHz B mode ultrasound. Both topically applied glucocorticosteroids lead to a significant decrease in skin thickness. In contrast to the glucocorticosteroid-induced atrophy, calcipotriol application on normal skin leads to an increase in skin thickness in all volunteers. The effect remains constant for the duration of treatment. The cause of this increase seems to be an irritative reaction of the skin which was histologically investigated in one volunteer. The histological features of this reaction are characteristic for a subacute dermatitis. The implications of these findings for the therapeutic mechanism of calcipotriol are discussed.

© 1994 S. Karger AG, Basel


  

Author Contacts

Jean Lévy, Human Pharmacology/Dermatology, Schering AG, Müllerstrasse 178, D-13342 Berlin (FRG)

  

Article Information

Received: January 11, 1993
Accepted: March 19, 1993
Published online: March 31, 2009
Number of Print Pages : 6

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 7, No. 4, Year 1994 (Cover Date: 1994)

Journal Editor: Lademann J. (Berlin)
ISSN: 1660-5527 (Print), eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 1/11/1993
Accepted: 3/19/1993
Published online: 3/31/2009
Issue release date: 1994

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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