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Table of Contents
Vol. 9, No. 2, 1996
Issue release date: 1996
Section title: Original Research Article
Skin Pharmacol 1996;9:111–119
(DOI:10.1159/000211406)

Cutaneous Permeability Barrier Repair following Various Types of Insults: Kinetics and Effects of Occlusion

Taljebini M. · Warren R. · Mao-Qiang M. · Lane E. · Elias P.M. · Feingold K.R.
Department of Medicine and Dermatology, University of California, San Francisco, and Metabolism Section, Medical Service, and Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, Calif., and Proctor & Gamble Company, Sharon Woods Technical Center, Cincinnati, Ohio, USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: February 15, 1995
Accepted: June 14, 1995
Published online: March 31, 2009
Issue release date: 1996

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Previous studies have shown that acute disruption of the cutaneous permeability barrier by acetone results in an initial rapid phase of repair followed by a later, slower phase. In the present study, we demonstrate that manipulations which disrupt the barrier by other mechanisms, such as tape stripping or detergent treatment, have a similar pattern of barrier repair. In all three models, the return of lipid to the stratum corneum parallels the normalization of barrier function, and occlusion immediately after disrupting the barrier blocks both the return of lipid and the normalization of function. Moreover, occlusion beginning 6-8 h following barrier disruption blocks the late, slower phase of repair, indicating that the late phase can be inhibited independently of the initial phase. Lastly, both severe and relatively minor perturbations of the barrier elicit a repair response with a similar kinetic pattern. In summary, the present study demonstrates that barrier repair responses are similar regardless of the etiology or extent of barrier disruption.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: February 15, 1995
Accepted: June 14, 1995
Published online: March 31, 2009
Issue release date: 1996

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.