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Table of Contents
Vol. 9, No. 4, 1996
Issue release date: 1996
Section title: Original Research Article
Skin Pharmacol 1996;9:259–269
(DOI:10.1159/000211423)

In vitro Study of Percutaneous Absorption, Cutaneous Bioavailability and Bioequivalence of Zinc and Copper from Five Topical Formulations

Pirot F.a · Millet J.b · Kalia Y.N.c · Humbert P.a
aDepartment of Functional Dermatology, University Hospital, and bLaboratory of Galenic Pharmacy, University of Besançon, France; cDepartment of Pharmacy, University of California, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 11/17/1995
Accepted: 3/13/1996
Published online: 3/31/2009
Issue release date: 1996

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Percutaneous absorption and cutaneous bioavailability of zinc and copper from zinc 2-pyrrolidone 5-carboxylate (ZnPC), zinc oxide (ZnO), zinc sulfate (ZnSO4), copper 2-pyrrolidone 5-carboxylate (CuPC) and copper sulfate (CuSO4) were compared using 5 formulations (3 emulsions and 2 ointments) that were applied topically on human skin in vitro. After application for 72 h, percutaneous absorption of zinc from ointments containing ZnO and ZnSO4 was found to be lower than that from a ZnPC-containing emulsion (0.36 and 0.34 versus 1.60% of applied dose). In the case of copper, the flux after a 72-hour treatment period showed that there had been minimal release from CuPC- and CuSO4-containing formulations (approximately 5 ng/cm2/h). All formulations used in this study effected an increase in zinc and copper concentrations in whole skin and epidermis. Bioequivalence of the 5 formulations based on pharmacokinetic results was assessed, and salt and vehicle effects were discussed.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 11/17/1995
Accepted: 3/13/1996
Published online: 3/31/2009
Issue release date: 1996

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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