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Table of Contents
Vol. 22, No. 3, 2009
Issue release date: April 2009
Section title: Original Paper
Skin Pharmacol Physiol 2009;22:158–165
(DOI:10.1159/000211912)

Laser-Induced Fluorescence and Reflectance Spectroscopy for the Discrimination of Basal Cell Carcinoma from the Surrounding Normal Skin Tissue

Drakaki E.a · Kaselouris E.a · Makropoulou M.a · Serafetinides A.A.a · Tsenga A.b · Stratigos A.J.c · Katsambas A.D.c · Antoniou C.c
aPhysics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, bIASO Hospital and cDepartment of Dermatology, University of Athens, Hospital A. Syggros, Athens, Greece

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 16, 2008
Accepted: February 20, 2009
Published online: April 08, 2009
Issue release date: April 2009

Number of Print Pages: 8
Number of Figures: 8
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

The object of this study was to investigate whether laser-induced skin autofluorescence (LIF) and/or light reflectance spectra could provide a useful contrast between basal cell carcinoma (BCC) tissues and the surrounding healthy skin. Unstained human skin samples, excised from humans undergoing biopsy examination, were irradiated with a nitrogen laser (λ = 337 nm) for excitation of autofluorescence and a tungsten halogen lamp for the reflectance measurements. The ex vivo spectroscopic results were correlated with the histopathology images to distinguish the areas of BCC from those of the surrounding health skin. A simple spectral analysis technique was also applied for better skin diagnosis. In conclusion, it seems that LIF and reflectance spectra could be used to differentiate neoplastic from normal skin tissue using an appropriate classification model analysis.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 16, 2008
Accepted: February 20, 2009
Published online: April 08, 2009
Issue release date: April 2009

Number of Print Pages: 8
Number of Figures: 8
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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