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Table of Contents
Vol. 9, No. 5, 2009
Issue release date: November 2009
Section title: Review
Pancreatology 2009;9:583–600
(DOI:10.1159/000212085)

A Fuller Understanding of Pancreatic Neuroendocrine Tumours Combined with Aggressive Management Improves Outcome

Ong S.L. · Garcea G. · Pollard C.A. · Furness P.N. · Steward W.P. · Rajesh A. · Spencer L. · Lloyd D.M. · Berry D.P. · Dennison A.R.
Departments of aHepatobiliary and Pancreatic Surgery, bHistopathology and cRadiology, Leicester General Hospital, dDepartment of Oncology, University Hospitals of Leicester, and eDepartment of Hepatobiliary and Pancreatic Surgery, Leicester Royal Infirmary, Leicester, UK

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 8/4/2009

Number of Print Pages: 18
Number of Figures: 4
Number of Tables: 10

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN

Abstract

Background: Neuroendocrine tumours of the pancreas (PNETs) represent 1–2% of all pancreatic tumours. The terms ‘islet cell tumours’ and ‘carcinoids’ of the pancreas should be avoided. The aim of this review is to offer an overview of the history and diagnosis of PNETs followed by a discussion of the available treatment options. Methods: A search on PubMed using the keywords ‘neuroendocrine’, ‘pancreas’ and ‘carcinoid’ was performed to identify relevant literature over the last 30 years. Results: The introduction of a revised classification of neuroendocrine tumours by the World Health Organisation (WHO) in 2000 significantly changed our understanding of and approach to the management of these tumours. Advances in laboratory and radiological techniques have also led to an increased detection of PNETs. Surgery remains the only treatment that offers a chance of cure with increasing number of non-surgical options serving as beneficial adjuncts. The better understanding of the behaviours of PNETs together with improvements in tumour localisation has resulted in a more aggressive management strategy with a concomitant improvement in symptom palliation and a prolongation of survival. Conclusion: Due to their complex nature and the wide range of therapeutic options, the involvement of specialists from all necessary disciplines in a multidisciplinary team setting is vital to provide optimal treatment of this disease.


  

Author Contacts

Seok Ling Ong
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital
Gwendolen Road
Leicester LE4 5PW (UK)
Tel. +44 116 258 8110, Fax +44 116 258 4708, E-Mail seokling.ong@googlemail.com

  

Article Information

Published online: August 4, 2009
Number of Print Pages : 18
Number of Figures : 4, Number of Tables : 10, Number of References : 130

  

Publication Details

Pancreatology

Vol. 9, No. 5, Year 2009 (Cover Date: November 2009)

Journal Editor: Urrutia R. (Rochester, Minn.)
ISSN: 1424-3903 (Print), eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 8/4/2009

Number of Print Pages: 18
Number of Figures: 4
Number of Tables: 10

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


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