Cover

Food Factors for Health Promotion

Editor(s): Yoshikawa T. (Kyoto) 
Table of Contents
Vol. 61, No. , 2009
Section title: Life-style Related Diseases
Yoshikawa T (ed): Food Factors for Health Promotion. Forum Nutr. Basel, Karger, 2009, vol 61, pp 104–116
(DOI:10.1159/000212743)

Soybean Isoflavones in Bone Health

Ishimi Y.
Project for Bio-index, Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Life-style Related Diseases

Published online: 4/7/2009
Cover Date: 2009

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9097-6 (Print)
eISBN: 978-3-8055-9098-3 (Online)

Abstract

Soybean isoflavones are structurally similar to estrogen, bind to estrogen receptors, and exhibit weak estrogenic activity. It has been reported that isoflavones play an important role in the prevention of hormone-dependent diseases, including osteoporosis, cardiovascular diseases, cancer, and postmenopausal syndrome. There are many researches indicating isoflavones prevent bone loss caused by estrogen deficiency in animal models. Furthermore, it has been demonstrated that a combination of isoflavone treatment and exercise cooperatively prevented bone loss in the estrogen-deficient status. Epidemiological studies demonstrated the relationship between the lower incidence of osteoporosis in Asian women and a diet rich in soy foods. Although a number of observational studies confirm the findings from the animal studies, the results from intervention studies are still controversial. One of the potential reasons for these inconsistencies could be individual differences in the isoflavone metabolism. Recently, it has been suggested that the clinical effectiveness of isoflavones might partly depend on the ability to produce equol, a gut bacterial metabolite of daidzein showing stronger estrogenic activity than the predominant isoflavones. Several candidate bacteria responsible for equol production have been suggested, for example Lactococcus 20-92 strain. From these findings, food factors enhancing equol production have received great deal of attention recently. On the other hand, safety assessment of isoflavones has been conducted by the Japanese Food Safety Commission. Further studies are required to address the numerous questions on the potential benefits, mechanisms of action, and safety of isoflavones.


  

Author Contacts

Dr. Yoshiko Ishimi, Project for Bio-index, Nutritional Epidemiology Program, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636 (Japan), Tel. +81 3 3203 5389, Fax +81 3 3203 7350, E-Mail ishimi@nih.go.jp

  

Article Information

Published online: April 07, 2009
Number of Print Pages : 13

  

Publication Details

Book Serie: Forum of Nutrition, Vol. 61, Year 2009

Editor(s): Elmadfa, I. (Vienna)
ISSN: 1660-0347 (Print), eISSN: 1662-2987 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1660-0347

Book Title: Food Factors for Health Promotion

Editor(s): Yoshikawa T (ed)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1660-0347&volume=61


Article / Publication Details

First-Page Preview
Abstract of Life-style Related Diseases

Published online: 4/7/2009
Cover Date: 2009

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9097-6 (Print)
eISBN: 978-3-8055-9098-3 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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