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Food Factors for Health Promotion

Editor(s): Yoshikawa T. (Kyoto) 
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Yoshikawa T (ed): Food Factors for Health Promotion. Forum Nutr. Basel, Karger, 2009, vol 61, pp 129–135
(DOI:10.1159/000212745)
Life-style Related Diseases

Astaxanthin Protects Neuronal Cells against Oxidative Damage and Is a Potent Candidate for Brain Food

Liu X. · Osawa T.
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Science, Nagoya University, Nagoya, Japan Yoshikawa T (ed): Food Factors for Health Promotion. Forum Nutr. Basel, Karger, 2009, vol 61, pp 129–135 (DOI:10.1159/000212745)

Abstract

Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Based on the report claiming that AST could cross the brain-blood barrier, the aim of this study was to investigate the neuroprotective effect of AST by using an oxidative stress-induced neuronal cell damage system. The treatment with DHA hydroperoxide (DHA-OOH) or 6-hydroxydopamine (6-OHDA), either of which is a reactive oxygen species (ROS)-inducing neurotoxin, led to a significant decrease in viable dopaminergic SH-SY5Y cells by the MTT assay, whereas a significant protection was shown when the cells were pretreated with AST. Moreover, 100 nM AST pretreatment significantly inhibited intracellular ROS generation that occurred in either DHA-OOH- or 6-OHDA-treatedcells. The neuroprotective effect of AST is suggested to be dependent upon its antioxidant potential and mitochondria protection; therefore, it is strongly suggested that treatment with AST may be effective for oxidative stress-associated neurodegeneration and a potential candidate for natural brain food.

 goto top of outline Author Contacts

Dr. Toshihiko Osawa, Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Science, Nagoya University, Furo-cho, Nagoya 464-8601 (Japan), Tel. +81 52 789 4125, Fax +81 52 789 5296, E-Mail osawat@agr.nagoya-u.ac.jp


 goto top of outline Article Information

Published online: April 07, 2009
Number of Print Pages : 7


 goto top of outline Publication Details

Book Serie: Forum of Nutrition, Vol. 61, Year 2009

Editor(s): Elmadfa, I. (Vienna)
ISSN: 1660-0347 (Print), eISSN: 1662-2987 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1660-0347

Book Title: Food Factors for Health Promotion

Editor(s): Yoshikawa T (ed)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1660-0347&volume=61


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