Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Based on the report claiming that AST could cross the brain-blood barrier, the aim of this study was to investigate the neuroprotective effect of AST by using an oxidative stress-induced neuronal cell damage system. The treatment with DHA hydroperoxide (DHA-OOH) or 6-hydroxydopamine (6-OHDA), either of which is a reactive oxygen species (ROS)-inducing neurotoxin, led to a significant decrease in viable dopaminergic SH-SY5Y cells by the MTT assay, whereas a significant protection was shown when the cells were pretreated with AST. Moreover, 100 nM AST pretreatment significantly inhibited intracellular ROS generation that occurred in either DHA-OOH- or 6-OHDA-treatedcells. The neuroprotective effect of AST is suggested to be dependent upon its antioxidant potential and mitochondria protection; therefore, it is strongly suggested that treatment with AST may be effective for oxidative stress-associated neurodegeneration and a potential candidate for natural brain food.
Dr. Toshihiko Osawa, Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Science, Nagoya University, Furo-cho, Nagoya 464-8601 (Japan), Tel. +81 52 789 4125, Fax +81 52 789 5296, E-Mail firstname.lastname@example.org
Published online: April 07, 2009
Number of Print Pages : 7
Book Serie: Forum of Nutrition, Vol. 61, Year 2009
Editor(s): Elmadfa, I. (Vienna)
ISSN: 1660-0347 (Print), eISSN: 1662-2987 (Online)
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Book Title: Food Factors for Health Promotion
Editor(s): Yoshikawa T (ed)
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Copyright / Drug Dosage
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