Cover

Food Factors for Health Promotion

Editor(s): Yoshikawa T. (Kyoto) 
Table of Contents
Vol. 61, No. , 2009
Section title: Chemoprevention and Cancer
Yoshikawa T (ed): Food Factors for Health Promotion. Forum Nutr. Basel, Karger, 2009, vol 61, pp 156–169
(DOI:10.1159/000212748)

Molecular Basis for Cancer Chemoprevention by Green Tea Polyphenol EGCG

Tachibana H.
Department of Bioscience and Biotechnology, Faculty of Agriculture, and Bio-Architecture Center, Kyushu University, Fukuoka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Chemoprevention and Cancer

Published online: 4/7/2009
Cover Date: 2009

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9097-6 (Print)
eISBN: 978-3-8055-9098-3 (Online)

Abstract

For the past two decades, many researchers have been investigating the potential cancer-preventive and therapeutic effects of green tea. (–)-Epigallocatechin-3-O-gallate (EGCG) has been shown to be the most active and major polyphenolic compound from green tea. The mechanisms of action of EGCG have been extensively investigated. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently, we have identified the 67-kDa laminin receptor (67LR) as a cell surface EGCG receptor that confers EGCG responsiveness to many cancer cells at physiological concentrations. This article reviews some of the reported mechanisms and possible targets for the action of EGCG. We especially focus on the current understanding of the signaling pathway for physiologically relevant EGCG through the 67LR for cancer prevention. Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Chemoprevention and Cancer

Published online: 4/7/2009
Cover Date: 2009

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9097-6 (Print)
eISBN: 978-3-8055-9098-3 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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