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Vol. 6, No. 6, 1999
Issue release date: December 1999
Section title: Original Article · Originalarbeit
Forsch Komplementärmed 1999;6:311–320
(DOI:10.1159/000021286)

Independent Replication of Pre-Clinical Research in Homoeopathy: A Systematic Review

Vickers A.J.
Royal London Homoeopathic Hospital

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 11/17/2004

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK

Abstract

Summary

Objective: To determine whether any pre-clinical research in homoeopathy has been independently replicated. Search Strategy:CISCOM was searched using the key words ‘homeopathy’ and ‘basic research’. Further references were obtained from reviews, bibliographies, citation tracking and contact with experts. Selection Criteria:Studies comparing the effects of one or more homoeopathic medicines to no homoeopathic treatment on any live biological material apart from humans or animals under veterinary care. Research on intoxication and basophil degranulation was excluded. Data Collection and Analysis: Publications were grouped in experimental models. Studies were considered to comprise the same model if the outcome variable, biological material and homoeopathic treatment were the same. Publications relating to each experimental model were then arranged in chronological order. A model was considered to have been independently replicated if the first author was different and fewer than half of all authors had previously published research using that model. Results: 120 papers reported 61 different experimental models. Only three models were investigated by different research teams: growth of yeast, growth of wheat coleoptiles and ultra-violet-induced erythema in albino guinea pigs. In the case of yeast, attempts to replicate findings showing increased growth after treatment with Pulsatilla were unsuccessful. For wheat, two experiments by different research teams were conducted, but no single hypothesis was tested in both papers with the same result. Different research teams conducted very similar experiments on erythema treatment by Apis, but the methodological quality of the publications was low. Conclusions:There is a lack of independent replication of any pre-clinical research in homoeopathy. In the few instances where a research team has set out to replicate the work of another, either the results were negative or the methodology was questionable.


  

Publication Details

Forschende Komplementärmedizin
Offizielles Organ der Schweizerischen Medizinischen Gesellschaft für Phytotherapie, European Society for Classical Natural Medicine

Vol. 6, No. 6, Year 1999 (Cover Date: December 1999)

Journal Editor: M. Bühring, München, Germany, K. Linde, München, Germany, W. Marktl, Wien Austria, D. Melchart, München, Germany, K.L. Resch, Bad Elster, Germany, R. Saller, Zürich, Switzerland, M. Ullmann, München, Germany
ISSN: 1021–7096 (print), 1421–9999 (Online)

For additional information: http://www.karger.com/journals/fkm


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 11/17/2004

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-4119 (Print)
eISSN: 1661-4127 (Online)

For additional information: http://www.karger.com/FOK


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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