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Table of Contents
Vol. 52, No. 1, 2009
Issue release date: May 2009
Section title: Original Paper
Intervirology 2009;52:43–48

An Open Pilot Study Exploring the Efficacy of Fluvastatin, Pegylated Interferon and Ribavirin in Patients with Hepatitis C Virus Genotype 1b in High Viral Loads

Sezaki H.a · Suzuki F.a · Akuta N.a · Yatsuji H.a · Hosaka T.a · Kobayashi M.a · Suzuki Y.a · Arase Y.a · Ikeda K.a · Miyakawa Y.b · Kumada H.a
aDepartment of Hepatology, Toranomon Hospital, and bMiyakawa Memorial Research Foundation, Tokyo, Japan
email Corresponding Author

Hitomi Sezaki, MD

Department of Hepatology, Toranomon Hospital


Tokyo 105-8470 (Japan)

Tel. +81 44 877 5111, Fax +81 44 860 1623, E-Mail hitomis@mx1.harmonix.ne.jp

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Objective: Response to pegylated (PEG) interferon (IFN) and ribavirin is achieved only in 40–50% of patients infected with hepatitis C virus (HCV) of genotype 1 in high viral loads, which needs to be improved. Methods: In an open-label pilot study, fluvastatin (HMG-CoA reductase inhibitor), 20 mg daily, was given along with PEG-IFN/ribavirin to 21 patients with chronic hepatitis C. They were followed for HCV RNA in serum. Results: During treatment for 48 weeks, HCV RNA was lost from serum in 93% of the patients. In the 15 patients who received 48-week therapy, a sustained virological response (SVR) with loss of HCV RNA 24 weeks after completion was achieved in 10 (67%), including 7 of the 9 (78%) male and 3 of the 6 (50%) female patients. In the remaining 6 patients who received 72-week therapy, SVR was gained in 4 (67%), including 1 of the 2 male and 3 of the 4 female patients aged 56, 58 and 62 years, respectively. Conclusion: Fluvastatin could be used safely to increase the response to PEG-IFN and ribavirin, especially in aged women who respond poorly to combined PEG-IFN/ribavirin.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 25, 2008
Accepted: May 03, 2009
Published online: April 17, 2009
Issue release date: May 2009

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

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