For Manuscript Submission, Check or Review Login please go to Submission Websites List.
For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.
An Open Pilot Study Exploring the Efficacy of Fluvastatin, Pegylated Interferon and Ribavirin in Patients with Hepatitis C Virus Genotype 1b in High Viral LoadsSezaki H.a · Suzuki F.a · Akuta N.a · Yatsuji H.a · Hosaka T.a · Kobayashi M.a · Suzuki Y.a · Arase Y.a · Ikeda K.a · Miyakawa Y.b · Kumada H.a
aDepartment of Hepatology, Toranomon Hospital, and bMiyakawa Memorial Research Foundation, Tokyo, Japan Corresponding Author
Hitomi Sezaki, MD
Department of Hepatology, Toranomon Hospital
Tokyo 105-8470 (Japan)
Tel. +81 44 877 5111, Fax +81 44 860 1623, E-Mail firstname.lastname@example.org
Objective: Response to pegylated (PEG) interferon (IFN) and ribavirin is achieved only in 40–50% of patients infected with hepatitis C virus (HCV) of genotype 1 in high viral loads, which needs to be improved. Methods: In an open-label pilot study, fluvastatin (HMG-CoA reductase inhibitor), 20 mg daily, was given along with PEG-IFN/ribavirin to 21 patients with chronic hepatitis C. They were followed for HCV RNA in serum. Results: During treatment for 48 weeks, HCV RNA was lost from serum in 93% of the patients. In the 15 patients who received 48-week therapy, a sustained virological response (SVR) with loss of HCV RNA 24 weeks after completion was achieved in 10 (67%), including 7 of the 9 (78%) male and 3 of the 6 (50%) female patients. In the remaining 6 patients who received 72-week therapy, SVR was gained in 4 (67%), including 1 of the 2 male and 3 of the 4 female patients aged 56, 58 and 62 years, respectively. Conclusion: Fluvastatin could be used safely to increase the response to PEG-IFN and ribavirin, especially in aged women who respond poorly to combined PEG-IFN/ribavirin.
© 2009 S. Karger AG, Basel