Changes in Brain Glucose Metabolism as a Key to the Pathogenesis of Alzheimer’s DiseaseMeier-Ruge W. · Bertoni-Freddari C. · Iwangoff P.
aDivision of Gerontological Brain Research, Department of Pathology, University Medical School of Basel, Switzerland; bINCRA Gerontological Research Department, Ancona, Italy
The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is exclusively synthesized in the glycolytic pathway in the brain. This means that a single molecule of glucose synthesizes only two molecules of acetylcoenzyme A but 38 molecules of ATP. This is critically changed if glucose metabolism of the brain decreases in SDAT. β-Amyloid precursor protein (β-APP) of chromosome 21 is a regular protein of repair of any cellular membrane in the body. It is integrated into the cellular membranes and split off by proteases in the β-region. This process is ATP-dependent. If in SDAT ATP synthesis is critically lowered by a decreased glucose turnover, β-APP cannot be built into the cellular membranes and the β-APP molecule is not split off in the β-region either. The consequence is a generation of β-amyloid from β-APP fragments, which are progressively accumulated in senile plaques and vascular walls. The missing repair of cellular membranes and synapses in the brain results in nerve cell atrophy and a shrinkage of the brain. It is concluded that the cholinergic deficit, nerve cell atrophy and the amyloid accumulation in the brain are secondary phenomena caused by the 50–70% decline of glucose metabolism in SDAT.
W. Meier-Ruge, University Medical School of Basel, Schönbeinstrasse 40, CH–4003 Basel (Switzerland)
Received: November 29, 1993
Accepted: January 27, 1994
Published online: April 14, 2009
Number of Print Pages : 7
Gerontology (International Journal of Experimental, Clinical, Behavioural and Technological Gerontology)
Vol. 40, No. 5, Year 1994 (Cover Date: 1994)
Journal Editor: Wick G. (Innsbruck)
ISSN: 0304-324X (Print), eISSN: 1423-0003 (Online)
For additional information: http://www.karger.com/GER