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Vol. 43, No. 6, 1997
Issue release date: 1997
Section title: Clinical Section
Gerontology 1997;43:343–351
(DOI:10.1159/000213874)

Increased Water Diffusion in Cerebral White Matter in Alzheimer’s Disease

Hanyu H.a · Shindo H.b · Kakizaki D.b · Abe K.b · Iwamoto T.a · Takasaki M.a
Departments of aGeriatric Medicine and bRadiology, Tokyo Medical College, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Section

Received: 7/10/1996
Accepted: 10/24/1996
Published online: 4/15/2009
Issue release date: 1997

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

Abstract

We investigated the changes in water diffusion in the cerebral white matter in 19 patients with Alzheimer’s disease (AD), including 11 without and 8 with periventricular hyperintensity (PVH) lesions, using diffusion-weighted magnetic resonance imaging (MRI). The apparent diffusion coefficients in the anterior and posterior white matter were significantly higher in the 19 AD patients than in the 10 age-matched controls. The apparent diffusion coefficients were higher in patients with PVH than in those without. The anisotropic ratios, defined as diffusion restricted perpendicular to the direction of the nerve fibers, were significantly higher in AD patients, even in those without PVH, than in the controls. Our results suggest that mild myelin loss occurs in AD patients even in the apparently normal white matter. A definite loss of myelin and axons, including incomplete infarction, occurs in the white matter, as seen on T2-weighted images as PVH. Studies with diffusion-weighted MRI may allow the characterization of different pathological processes and enable the demonstration of underlying white matter lesions in AD that cannot be visualized by conventional MRI.

© 1997 S. Karger AG, Basel


  

Author Contacts

Haruo Hanyu, MD, Department of Geriatric Medicine, Tokyo Medical College, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160 (Japan), Tel.+81 333426111, Fax+81 33342 2305

  

Article Information

Received: July 10, 1996
Accepted: October 24, 1996
Published online: April 15, 2009
Number of Print Pages : 9

  

Publication Details

Gerontology (International Journal of Experimental, Clinical, Behavioural and Technological Gerontology)

Vol. 43, No. 6, Year 1997 (Cover Date: 1997)

Journal Editor: Wick G. (Innsbruck)
ISSN: 0304-324X (Print), eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


Article / Publication Details

First-Page Preview
Abstract of Clinical Section

Received: 7/10/1996
Accepted: 10/24/1996
Published online: 4/15/2009
Issue release date: 1997

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


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