Journal Mobile Options
Table of Contents
Vol. 112, No. 2, 2009
Issue release date: May 2009
Section title: Original Paper
Nephron Clin Pract 2009;112:c115–c120
(DOI:10.1159/000213899)

Tubular Proteinuria and Glomerular Filtration 6 Years after Puumala Hantavirus-Induced Acute Interstitial Nephritis

Miettinen M.H.a · Mäkelä S.M.b, d · Ala-Houhala I.O.b, d · Huhtala H.S.c · Kööbi T.e · Vaheri A.I.f · Pasternack A.I.b · Pörsti I.H.b, d · Mustonen J.T.b, d
aDepartment of Internal Medicine, Central Hospital of Jyväskylä, Jyväskylä, bMedical School, cTampere School of Public Health, University of Tampere,Departments of dInternal Medicine and eClinical Physiology, Tampere University Hospital, Tampere, and fDepartment of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

For eJournal Archive and eJournal Backfiles information please contact service@karger.com


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/4/2008
Accepted: 10/16/2008
Published online: 4/23/2009
Issue release date: May 2009

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC

Abstract

Background/Aims: We previously found increased urinary protein excretion, glomerular filtration rate (GFR) and blood pressure in a retrospective analysis of patients with previous nephropathia epidemica (NE). Here, we evaluated the long-term outcome after NE in a prospectively recruited patient group. Methods: Proteinuria, GFR and ambulatory 24-hour blood pressure were assessed 4–7 years (mean 6) after acute NE in 37 patients, and these values were compared to those from 38 seronegative controls. Results: Six years after NE, the prevalence of elevated urinary α1-microglobulin excretion was higher in the patients than controls (9/35 vs. 1/38; p = 0.005). The patients also had higher urinary protein excretion (0.17 ± 0.05 vs. 0.14 ± 0.04 g/day; p = 0.006), GFR (119 ± 19 vs. 109 ± 14 ml/min/1.73 m2; p = 0.016) and mean systolic (123 ± 11 vs. 117 ± 9 mm Hg; p = 0.012), nighttime systolic (109 ± 11 vs. 100 ± 9 mm Hg; p = 0.001) and nighttime diastolic blood pressure (70 ± 7 vs. 66 ± 7 mm Hg; p = 0.035) than the controls. Conclusions: These results confirm our previous findings of a higher prevalence of tubular proteinuria and increased urinary protein excretion, GFR and systolic blood pressure 6 years after acute NE.

© 2009 S. Karger AG, Basel


  

Author Contacts

Marja Miettinen, MD
Department of Internal Medicine, Central Hospital of Jyväskylä
Keskussairaalantie 19
FI–40620 Jyväskylä (Finland)
Tel. +358 14 269 1811, Fax +358 14 269 2711, E-Mail marja.miettinen@ksshp.fi

  

Article Information

Received: March 4, 2008
Accepted: October 16, 2008
Published online: April 23, 2009
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 2, Number of References : 22

  

Publication Details

Nephron Clinical Practice

Vol. 112, No. 2, Year 2009 (Cover Date: May 2009)

Journal Editor: El Nahas M. (Sheffield)
ISSN: 1660-2110 (Print), eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/4/2008
Accepted: 10/16/2008
Published online: 4/23/2009
Issue release date: May 2009

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.