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Table of Contents
Vol. 3, No. 5-6, 1974
Issue release date: 1974
Section title: Paper
Haemostasis 1974;3:257–270
(DOI:10.1159/000214064)

Adhesion of Human Blood Platelets to Glass and Polymer Surfaces

I. Studies with Platelets in Plasma

Mohammad S.F. · Hardison M.D. · Glenn C.H. · Morton B.D. · Bolan J.C. · Mason R.G.
Department of Pathology, University of North Carolina, Chapel Hill, N. C.

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 11/13/1974
Accepted: 2/3/1975
Published online: 4/16/2009
Issue release date: 1974

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: http://www.karger.com/PHT

Abstract

Platelet adhesion to glass, polyethylene, polyvinyl chloride, and Cuprophane has been studied by means of a method specific for quantitation of adhesion. Platelets adhered in larger numbers to polyethylene and polyvinyl chloride than to Cuprophane or glass regardless of the anticoagulant used. In citrated plasma, fewer platelets adhered to glass than to Cuprophane, although adhesion to glass and Cuprophane was nearly the same when EDTA or heparin was used as anticoagulant. The number of adherent platelets decreased appreciably from values obtained with citrated platelet-rich plasma, when EDTA or heparin was used as anticoagulant. Adhesiveness of normal platelets increased with age. A number of different pharmacologic and other agents were found to inhibit platelet adhesion to artificial surfaces. Acetylsalicylic acid and glucosamine were less effective inhibitors than sulfinpyrazone, imipramine, desipramine, amitriptyline, chlorpromazine, or PCMB. Penicillin did not inhibit adhesion. Donors deficient in factors VIII, XI, or XII or donors with von Willebrand’s disease showed normal platelet adhesiveness. Adhesiveness was markedly low in tests with blood from afibrinogenemic or thrombasthenic patients. Decreased adhesiveness of afibrinogenemic platelets could be corrected by addition of fibrinogen.

© 1974 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 11/13/1974
Accepted: 2/3/1975
Published online: 4/16/2009
Issue release date: 1974

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: http://www.karger.com/PHT


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