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Table of Contents
Vol. 76, No. 6, 2009
Issue release date: May 2009
Section title: Clinical Study
Oncology 2009;76:413–419
(DOI:10.1159/000215928)

Neoadjuvant 5 Fluorouracil-Cisplatin Chemoradiation Effect on Survival in Patients with Resectable Pancreatic Head Adenocarcinoma: A Ten-Year Single Institution Experience

Turrini O.a · Viret F.b · Moureau-Zabotto L.c · Guiramand J.a · Moutardier V.a · Lelong B.a · de Chaisemartin C.a · Giovannini M.d · Delpero J.-R.a
Departments of aSurgical Oncology, bMedical Oncology, cRadiotherapy, and dEndoscopy, Institut Paoli-Calmettes and Université de la Méditerranée Marseille, Marseille, France

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 10/13/2008
Accepted: 12/18/2008
Published online: 5/4/2009
Issue release date: May 2009

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objectives: It is the aim of this study to assess the outcome of patients who received neoadjuvant 5-fluorouracil-cisplatin chemoradiation (CRT) for stage I/III pancreatic adenocarcinoma. Methods: Eligible patients (n = 101) received radiation therapy (45 Gy) associated with continuous infusion of 5-fluorouracil accompanied by a cisplatin bolus. Results: Of the 102 patients enrolled in the study, 26 patients had progression of cancer during treatment and were deemed unresectable; 1 patient died during CRT of septic shock. Sixty-two of 75 remaining patients underwent pancreaticoduodenectomy. The overall median survival of all 102 patients in the study was 17 months, with a 5-year survival of 10%. For patients who underwent resection, the median survival was 23 months. Correspondingly, the median survival was 11 months for the 40 unresected patients (p = 0.002). The 5-year survivals for resected and unresected patients were 18 and 0% (p = 0.01), respectively. A complete pathological response to neoadjuvant CRT was noted for 8 patients (13%). Margin and lymph node positivity was present in 5 (8%) and 15 (24%) patients, respectively. There was documented local recurrence in 8 (13%) and distant recurrence in 36 (58%) patients, with the liver being the most common site. Conclusion: Neoadjuvant 5-fluorouracil-based CRT had a limited impact on survival but appeared to be associated with improved local control.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 10/13/2008
Accepted: 12/18/2008
Published online: 5/4/2009
Issue release date: May 2009

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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