Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 31, No. 4, 2009
Issue release date: June 2009
Section title: Stress
Editor's Choice -- Free Access
Dev Neurosci 2009;31:293–299

Prefrontal Plasticity and Stress Inoculation-Induced Resilience

Katz M.a · Liu C.b · Schaer M.c, d · Parker K.J.a · Ottet M.-C.c · Epps A.a · Buckmaster C.L.a · Bammer R.b · Moseley M.E.b · Schatzberg A.F.a · Eliez S.c · Lyons D.M.a
Departments of aPsychiatry and bRadiology, Stanford University, Stanford, Calif., USA; cDivision of Child and Adolescent Psychiatry, Geneva University, Geneva, and dSignal Processing Institute, Swiss Federal Institute of Technology, Lausanne, Switzerland
email Corresponding Author

David M. Lyons

1201 Welch Rd


Stanford, CA 94305-5485 (USA)

Tel. +1 650 725 5931, Fax +1 650 498 7761, E-Mail dmlyons@stanford.edu

Do you have an account?

Login Information

Contact Information

I have read the Karger Terms and Conditions and agree.


Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Stress

Received: January 09, 2009
Accepted: January 09, 2009
Published online: June 17, 2009
Issue release date: June 2009

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.