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Vol. 36, No. 3, 2009
Issue release date: June 2009
Free Access
Transfus Med Hemother 2009;36:189–198
Review Article · Übersichtsarbeit

Prenatal RhD Testing: A Review of Studies Published from 2006 to 2008

Legler T.J.a · Müller S.P.a · Haverkamp A.a · Grill S.b · Hahn S.b
a Department of Transfusion Medicine, University Medical Center, Göttingen, Germany b University Women’s Hospital, Department Biomedicine, University Clinics, Basel, Switzerland


The availability of noninvasive prenatal diagnosis for the fetal RhD status (NIPD RhD) is an obvious benefit for alloimmunized pregnant women. This review gives information about the performance characteristics of current diagnostic technologies and recent promising proof-ofprinciple studies. Notably, during the past 3 years almost twice as much samples have been investigated with NIPD RhD compared with the studies from 1998 to 2005. Thus we have now a lot more information compared with the knowledge before 2006. There is no doubt that funding of the SAFE Network of Excellence (2004–2009) from the European Commission within the framework 6 program has massively increased the worldwide experience in NIPD RhD. In 2009 European funding has been stopped. Because of this large investment from public funding sources, it is now the duty of policy makers (scientific boards, patient groups, physician organizations, and health assurances) to discuss if targetedantenatal Rh prophylaxis should be introduced in German-speaking countries or which additional data are required to make a decision and how these additional studies should be funded.

 goto top of outline Author Contacts

Prof. Dr. med. Tobias J. Legler, Department of Transfusion Medicine, University Medical Center Göttingen, Georg August Universität, 37099 Göttingen, Germany, Tel. +49 551 39-2750, Fax -8691,

 goto top of outline Article Information

Received: January 21, 2009
Accepted: April 27, 2009
Published online: May 14, 2009
Number of Print Pages : 10

 goto top of outline Publication Details

Transfusion Medicine and Hemotherapy

Vol. 36, No. 3, Year 2009 (Cover Date: June 2009)

Journal Editor: Sibrowski W. (Münster)
ISSN: 1660-3796 (Print), eISSN: 1660-3818 (Online)

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