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Table of Contents
Vol. 55, No. 3, 2009
Issue release date: May 2009
Section title: Pharmacology
Chemotherapy 2009;55:189–196
(DOI:10.1159/000216836)

Antifungal Activity of Black Tea Polyphenols (Catechins and Theaflavins) against Candida Species

Sitheeque M.A.M. · Panagoda G.J. · Yau J. · Amarakoon A.M.T. · Udagama U.R.N. · Samaranayake L.P.
aFaculty of Dental Sciences, University of Peradeniya, Peradeniya, and bTea Research Institute of Sri Lanka, Talawakele, Sri Lanka; cOral Biosciences, Faculty of Dentistry, University of Hong Kong, Hong Kong, SAR, China

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology

Received: 7/15/2008
Accepted: 2/2/2009
Published online: 5/5/2009

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

Background/Aims: The polyphenols catechins and theaflavins in black tea have been shown to possess many medicinal properties, including anticancer activity and some antifungal characteristics, but there have been few studies of their anti-Candida activity. In this paper we report the results of our study of the anti-Candida activity of tea polyphenols. Methods: The effects of 4 different concentrations of catechins and theaflavins were evaluated on 5 isolates each of 5 Candida species employing an agar diffusion growth inhibition assay. The minimum inhibitory concentration (MIC) of the polyphenols against C. albicans was determined. The post-antifungal effect (PAFE) of the polyphenols for C. albicans was investigated. C. albicans cells exposed to polyphenols were studied using a scanning electron microscope (SEM). Results: Both polyphenols showed anti-Candida activity against all tested Candida species and demonstrated a MIC of 6.25 mg/ml for C. albicans. C. glabrata was found to be the most sensitive species followed by C. parapsilosis, C. albicans, C. krusei and C. tropicalis (p < 0.05 for all). Significant intraspecies variations in sensitivity were noted among C. parapsilosis and C. tropicalis (p < 0.001) for both polyphenols. Theaflavins displayed standard PAFE while catechins showed a paradoxical PAFE with all isolates of C. albicans. SEM revealed considerable cell wall damage of C. albicans cells exposed to the polyphenols. Conclusion: The study reveals for the first time the anti-Candida properties of black tea polyphenols that may find therapeutic applications in future.


  

Author Contacts

Prof. L.P. Samaranayake
Oral Biosciences, Faculty of Dentistry, University of Hong Kong
34 Hospital Road
Hong Kong, SAR (China)
Tel. +852 2859 0480, Fax +852 2547 6133, E-Mail lakshman@hku.hk

  

Article Information

Received: July 15, 2009
Accepted after revision: February 2, 2009
Published online: May 5, 2009
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 29

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)

Vol. 55, No. 3, Year 2009 (Cover Date: May 2009)

Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009-3157 (Print), eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


Article / Publication Details

First-Page Preview
Abstract of Pharmacology

Received: 7/15/2008
Accepted: 2/2/2009
Published online: 5/5/2009

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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