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Table of Contents
Vol. 26, Suppl. 1, 1996
Issue release date: 1996
Section title: Session III: Extrinsic Coagulation Pathway and Disease
Haemostasis 1996;26:60–65
(DOI:10.1159/000217242)

P-Selectin Induction of Tissue Factor Biosynthesis and Expression

Furie B. · Furie B.C.
Center for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, New England Medical Center and the Departments of Medicine and Biochemistry, Tufts University School of Medicine, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Session III: Extrinsic Coagulation Pathway and Disease

Published online: April 28, 2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: http://www.karger.com/PHT

Abstract

P-selectin on activated platelets and stimulated endothelial cells mediates cell adhesion with monocytes and neutrophils. Since activated platelets induce tissue factor on monocytes, we examined the effect of P-selectin on this activity. Chinese hamster ovary cells expressing P-selectin stimulated tissue factor activity in purified monocytes whereas untransfected Chinese hamster ovary cells and CHO cells expressing E-selectin did not. Anti-P-selectin antibodies inhibited these effects. Incubation of CHO:P-selectin with monocytes stimulates tissue factor mRNA development and the expression of tissue factor antigen on the monocyte surface. These results indicate that P-selectin upregulates the expression of tissue factor on monocytes.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Session III: Extrinsic Coagulation Pathway and Disease

Published online: April 28, 2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: http://www.karger.com/PHT


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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