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Vol. 10, No. 1, 2010
Issue release date: April 2010
Section title: Original Paper
Pancreatology 2010;10:33–38
(DOI:10.1159/000217604)

Are There Prognostic Factors Related to Recurrence in Pancreatic Endocrine Tumors?

Casadei R. · Ricci C. · Pezzilli R. · Campana D. · Tomassetti P. · Calculli L. · Santini D. · D’Ambra M. · Minni F.
Dipartimenti diaScienze Chirurgiche e Anestesiologiche, bMedicina Interna e Gastroenterologia, and cScienze Radiologiche e Istocitopatologiche, Alma Mater Studiorum, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/13/2008
Accepted: 4/25/2009
Published online: 3/19/2010

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN

Abstract

Aims: The aim of this study was to evaluate the rate, site, time of recurrence and prognostic factors related to the appearance of recurrences in patients affected by pancreatic endocrine tumors (PETs). Methods: Data from 67 consecutive patients with PETs who underwent R0 resection were analyzed. The prognostic factors considered were: gender, age, type of tumor, presence of symptoms, size of tumor, tumor node metastasis (TNM) stage, WHO classification and adjuvant therapy. Results: The recurrence rate was 24.6%, with a mean time of 7.3 ± 4.5 years. The majority were in the liver (75% of cases) and were rarely local (25%). Univariate analysis of the prognostic factors showed that the risk of recurrences is significantly higher in PETs in MEN-1 syndrome, in tumor size ≧4 cm, in the presence of liver metastases, in TNM stages III–IV and, finally, in PD-Cas and WD-Cas. Multivariate Cox regression analysis showed that only MEN-1 syndrome and the WHO classification were independent predictors of an increased risk of recurrence. Conclusions: Several prognostic factors were related to recurrences in PETs. MEN-1 syndrome and the WHO classification can be considered independent factors of an increased risk of recurrence.


  

Author Contacts

Riccardo Casadei, MD
Dipartimento di Scienze Chirurgiche e Anestesiologiche, Chirurgia Generale-Minni
Alma Mater Studiorum, Università di Bologna, Policlinico S. Orsola-Malpighi
Via Massarenti n.9, IT–40138 Bologna (Italy)
Tel. +39 051 341 541, Fax +39 051 341 483, E-Mail riccardo.casadei@aosp.bo.it

  

Article Information

Received: November 13, 2008
Accepted: April 25, 2009
Published online: March 19, 2010
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 16

  

Publication Details

Pancreatology

Vol. 10, No. 1, Year 2010 (Cover Date: April 2010)

Journal Editor: Urrutia R. (Rochester, Minn.)
ISSN: 1424-3903 (Print), eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/13/2008
Accepted: 4/25/2009
Published online: 3/19/2010

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


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