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Vol. 13, No. 1, 2010
Issue release date: September 2009
Section title: Original Paper
Public Health Genomics 2010;13:34–47
(DOI:10.1159/000217794)

Psychological and Behavioral Responses to Genetic Test Results Indicating Increased Risk of Obesity: Does the Causal Pathway from Gene to Obesity Matter?

Sanderson S.C. · Persky S. · Michie S.
aMount Sinai School of Medicine, Department of Genetics and Genomic Sciences, New York, N.Y., bNational Human Genome Research Institute, Bethesda, Md., USA; cUniversity College London, Department of Psychology, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/3/2008
Accepted: 2/10/2009
Published online: 5/4/2009

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 4

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG

Abstract

Background: Common obesity-associated genetic variants may exert their effects through increasing eating or decreasing metabolism. Such differences might influence individual responses to obesity genetic test results.Methods: This was an experimental analogue study: 191 participants were asked to imagine they had received a genetic test result indicating high eating-based (n = 37) or high metabolism-based (n = 41) risk of obesity, an enzyme test result indicating high eating-based (n = 35) or high metabolism-based (n = 41) risk of obesity, or no risk information (n = 37). Outcomes included perceived risk, self-efficacy (confidence in ability to eat healthily), response-efficacy (confidence that eating healthily will reduce risk), and intention to eat healthily. Results: The groups receiving increased obesity risk information reported greater perceived risk and intention to eat healthily than the no risk information group (both p < 0.01). There were main effects of test type on perceived risk (genetic vs. enzyme: 3.91 vs. 3.55, p = 0.031) and of causal pathway on worry (eating vs. metabolism: 3.33 vs. 2.86, p = 0.049), but no effects of either manipulation on any other outcomes. Conclusion: Personal risk information indicating increased obesity risk may increase motivation to eat healthily, regardless of whether the risk is described as genetic or non-genetic or as acting through an eating-based or metabolism-based causal pathway.


  

Author Contacts

Saskia C. Sanderson, PhD
Mount Sinai School of Medicine, Department of Genetics and Genomic Sciences
Icahn Medical Institute, Floor 14, 1425 Madison Avenue
New York, NY 10029 (USA)
Tel. +1 212 659 7600, Fax +1 212 360 1809, E-Mail saskia.sanderson@mssm.edu

  

Article Information

Received: October 3, 2008
Accepted: February 10, 2009
Published online: May 4, 2009
Number of Print Pages : 14
Number of Figures : 1, Number of Tables : 4, Number of References : 56

  

Publication Details

Public Health Genomics

Vol. 13, No. 1, Year 2010 (Cover Date: September 2009)

Journal Editor: Knoppers B.M. (Montreal, Que.), Brand A. (Maastricht), Burke W. (Seattle, Wash.), Khoury M.J. (Atlanta, Ga.)
ISSN: 1662-4246 (Print), eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/3/2008
Accepted: 2/10/2009
Published online: 5/4/2009

Number of Print Pages: 14
Number of Figures: 1
Number of Tables: 4

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


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