MicroRNAs in Diabetes: Tiny Players in Big DiseasePandey A.K. · Agarwal P. · Kaur K. · Datta M.
Institute of Genomics and Integrative Biology, CSIR, Delhi
MicroRNAs (miRNAs) are a novel group of universally present small non-coding RNAs that have been implicated in wide ranging physiological processes and thereby are critical in the manifestation of diverse diseases. Since their discovery as developmental regulators in C.elegans, they have come a long way and are currently associated with normal and diverse pathophysiological states including Parkinson’s syndrome, cardiac hypertrophy, viral infection, diabetes and several types of cancer. Of special significance is their involvement in diabetes, an area in which several emerging reports point to the fact that these small RNA species could be special and critical in this complex disease and they or their specific inhibitors may be exploited as targets for therapeutic intervention. The stable nature of these miRNAs over mRNAs is an added advantage of them being projected for the same. This review focuses on and discusses the current diabetic epidemic and the potential role(s) of these miRNAs in various physiological processes that lead to the diabetic phenotype with an objective of better understanding the emerging mechanisms of these small molecules in the development and progression of diabetes and its complications.
© 2009 S. Karger AG, Basel
Dr. Malabika Datta
Institute of Genomics and Integrative Biology
Mall Road, Delhi-110 007 (India)
Tel. +91 11 27667439, Fax: +91 11 27667471
Accepted: March 20, 2009
Published online: May 06, 2009
Number of Print Pages : 12
Cellular Physiology and Biochemistry (International Journal of Experimental Cellular Physiology, Biochemistry andPharmacology)
Vol. 23, No. 4-6, Year 2009 (Cover Date: 2009)
Journal Editor: F. Lang, Tübingen
ISSN: 1015–8987 (Print), eISSN: 1421–9778 (Online)
For additional information: http://www.karger.com/journals/cpb