The lack of effective treatments for many forms of hearing and vestibular disorders has produced interest in virally mediated gene therapies. However, to develop a gene therapy strategy that would successfully treat inner ear disorders, appropriate viral vectors capable of transfecting cochlear and support cells must be identified. While virally mediated gene transfer into the inner ear has been accomplished using herpes simplex type I virus, vaccinia virus, retroviruses, adenovirus, and adeno-associated virus (AAV), we will restrict our discussion to AAV and adenoviral vectors. Issues such as vector toxicity and load, viral serotype and backbone, and promoter specificity are discussed and contrasted for both in vivo vs. in vitro inner ear gene transfer.
Anne E. Luebke, PhD, Department of Biomedical Engineering, University of Rochester, Medical Center Box 603, 601 Elmwood Ave. MC68547, Rochester, NY 14642 (USA), Tel. +1 585 273 1635, Fax +1 585 276 5334, E-Mail Anne_Luebke@urmc.rochester.edu
Published online: June 02, 2009
Number of Print Pages : 12
Book Serie: Advances in Oto-Rhino-Laryngology, Vol. 66, Year 2009
Editor(s): Arnold, W. (München)
ISSN: 0065-3071 (Print), eISSN: 1662-2847 (Online)
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Book Title: Gene Therapy of Cochlear Deafness
(Present Concepts and Future Aspects)
Editor(s): Ryan AF (ed)
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