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Original Paper

Free Access

Structural Differences within Negative and Depressive Syndrome Dimensions in Schizophrenia, Organic Brain Disease, and Major Depression: A Confirmatory Factor Analysis of the Positive and Negative Syndrome Scale

Eisenberg D.P.a · Aniskin D.B.a · White L.b · Stein J.A.c · Harvey P.D.d · Galynker I.I.a

Author affiliations

aDepartment of Psychiatry, Beth Israel Medical Center, New York, N.Y., bClinical Neuroscience Center, Pilgrim Psychiatric Center, Brentwood, N.Y., cDepartment of Psychology, University of California, Los Angeles, Calif., and dDepartment of Psychiatry, Emory University, Atlanta, Ga., USA

Corresponding Author

Igor I. Galynker, MD, PhD

Department of Psychiatry, Beth Israel Medical Center

First Avenue & 16th Street

New York, NY 10003 (USA)

Tel. +1 212 420 4535, Fax +1 212 844 7659, E-Mail igalynke@chpnet.org

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Psychopathology 2009;42:242–248

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Abstract

Objective: The emerging dimensional approach to classification and treatment of psychiatric disorders calls for better understanding of diagnosis-related variations in psychiatric syndromes and for proper validation of psychometric scales used for the evaluation of those syndromes. This study tested the hypothesis that negative and depressive syndromes as measured by the Positive and Negative Syndrome Scale (PANSS) are consistent across different diagnoses. Method: We administered the PANSS to subjects with schizophrenia (n = 305), organic brain disease (OBD, n = 66) and major depressive disorder (MDD, n = 75). Confirmatory factor analysis (CFA) was used to establish if the PANSS items for negative symptoms and for depression fit the hypothesized factor structure and if the item factor loadings were similar among the diagnostic groups. Results: The negative and depressive symptom subscales fit well according to a variety of fit indexes for all groups individually after some modest model modification. However, multisample modeling procedures indicated that the pattern of factor loadings was significantly different among the groups in most cases. Conclusion: The results of this study indicate diagnosis-related variations in the negative and depressive syndrome dimensions in schizophrenia, OBD and MDD. These results also validate limited use of the PANSS for evaluation of negative and depressive syndromes in disorders other than schizophrenia. Larger studies are warranted to further evaluate clinical and nosologic significance of diagnostic categories, dimensions and structures of psychiatric syndromes.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 30, 2007
Accepted: April 17, 2008
Published online: May 16, 2009
Issue release date: June 2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP


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