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Table of Contents
Vol. 82, No. 4, 2009
Issue release date: June 2009
Section title: Original Paper
Urol Int 2009;82:459–463
(DOI:10.1159/000218538)

Role of Calcium in the Aggregation of Particles Coated by Urinary Macromolecules

Baumann J.M.a · Affolter B.a · Caprez U.a · Clivaz C.a · von Arx U.b
aStone Research Center Viollier, and bBern University of Applied Sciences, Division of Architecture, Wood and Civil Engineering, Research and Development, Biel, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/31/2008
Accepted: 3/31/2008
Published online: 6/8/2009
Issue release date: June 2009

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Objectives: In urine, aggregation (AGN) of crystal occurs although they are coated by negatively charged urinary macromolecules (UM) and isolated at a distance from each other, where attraction forces become extremely weak. Calcium (Ca) bridges or viscous binding by UM could explain this AGN. Methods: Suspensions of Ca oxalate monohydrate (COM) and carboxylated latex (CL) were prepared in buffered water and UM solutions which were obtained from the urine of 6 healthy men. Surface potential or zetapotential (ZP) of the particles was measured at various concentrations of Ca and UM. AGN of CL was monitored determining particle size and optical density. Results: The ZP of COM was neutralized by Ca and stabilized around –15 mV by UM. In CL, a stable ZP of about –20 mV was achieved at >3 mM Ca. However, to induce AGN further addition of Ca was necessary. AGN then increased independently of ZP with increasing Ca and decreased with increasing UM concentration. Conclusions: In CL, two different Ca effects could be distinguished, one on ZP and another on AGN. The latter is probably based on the formation of Ca bridges between particles and is inhibited by a steric barrier of adsorbed UM. A similar mechanism is postulated for crystal aggregation.

© 2009 S. Karger AG, Basel


  

Author Contacts

Prof. J.M. Baumann
Alpenstrasse 21a
CH–2502 Biel/Bienne (Switzerland)
Tel +41 32 323 1010, Fax +41 32 323 1025
E-Mail johannes.denise.baumann@bluewin.ch

  

Article Information

Received: January 31, 2008
Accepted after revision: March 31, 2008
Published online: June 08, 2009
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 0, Number of References : 17

  

Publication Details

Urologia Internationalis

Vol. 82, No. 4, Year 2009 (Cover Date: June 2009)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/31/2008
Accepted: 3/31/2008
Published online: 6/8/2009
Issue release date: June 2009

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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