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Influence of Early Nutritional Components on the Development of Murine Autoimmune DiabetesMueller D.B.a · Koczwara K.a · Mueller A.S.c, d · Pallauf J.c · Ziegler A.-G.a, b · Bonifacio E.e
aInstitut für Diabetesforschung der Forschergruppe Diabetes e.V. am Helmholtz Zentrum München and bKlinik für Endokrinologie, Diabetologie und Suchtmedizin, Klinikum Schwabing, Städt. Klinikum München GmbH, München, cInstitute of Animal Nutrition and Nutritional Physiology, University Giessen, Giessen, dInstitute of Agricultural and Nutritional Sciences, Preventive Nutrition Group, University Halle, Halle/Saale, and eCenter for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany Corresponding Author
Dr. Kerstin Koczwara
Institut für Diabetesforschung am Helmholtz Zentrum München
Ingolstädter Landstrasse 1, DE–85764 Neuherberg (Germany)
Tel. +49 89 31 87 39 06, Fax +49 89 30 81 733
Background/Aims: Infant diet is suggested to modify autoimmune diabetes risk. The aim of this study was to determine whether infant food components affect diabetes development in the nonobese autoimmune diabetes (NOD) mouse. Methods: A basal low-diabetogenic diet was identified by feeding litter-matched female NOD mice standardized diets with and without casein and wheat proteins after weaning. In subsequent trials, basal diet with supplements of wheat (5, 10 and 30%), gluten, wheat globulin/albumin, corn (5%), potato (5%), apple (5%) or carrot (5%) was fed to litter-matched female NOD mice after weaning. Mice were followed for diabetes development and insulin autoantibodies. Results: A casein- and wheat-free diet was associated with the lowest rate of diabetes development (37% by age 25 weeks). Increased diabetes rates were observed when the basal diet was supplemented with 5% wheat (71% by age 25 weeks; p = 0.023) and 5% corn (57% by age 25 weeks; p = 0.05). Increasing wheat concentrations returned diabetes development to that in basal diet-fed mice. Other food supplements had no or minimal effects on diabetes development. Conclusions: Early supplementation of a basal low-diabetogenic diet with low concentrations of the cereals wheat or corn is associated with a moderate increase in the rate of diabetes. Removal of cereals, however, does not abrogate diabetes development in NOD mice.
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