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Table of Contents
Vol. 96, No. 4, 2009
Issue release date: November 2009
Section title: Original Paper
Neonatology 2009;96:259–264
(DOI:10.1159/000220765)

Ventilator Gas Flow Rates Affect Inspiratory Time and Ventilator Efficiency Index in Term Lambs

Bach K.P.a · Kuschel C.A.a, c · Oliver M.H.a, b · Bloomfield F.H.a–c
aLiggins Institute and bNational Research Centre for Growth and Development, University of Auckland, and cNewborn Services, National Women’s Health, Auckland District Health Board, Auckland, New Zealand

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 12, 2008
Accepted: October 08, 2008
Published online: May 27, 2009
Issue release date: November 2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Despite increasing survival in the smallest preterm infants, the incidence of chronic lung disease has not decreased. Research into ventilatory strategies has concentrated on minimising barotrauma, volutrauma and atelectotrauma, but little attention has been paid to the role of bias gas flow rates and the potential for rheotrauma or shear stress injury. Ventilated preterm infants frequently receive relatively high gas flow rates. Objectives: We hypothesised that altering bias gas flow rates would change the efficiency of ventilation and thereby affect ventilatory parameters. Methods: We tested this hypothesis using an artificial lung followed by ventilation of 8 term lambs. Results: Between flows of 2 and 15 l/min, inflation time (Ti) in the artificial lung was inversely related to the bias gas flow rate. In the ventilated lambs, Ti was inversely related to flow rates up to 10 l/min, with no statistically significant effect at flow rates >10 l/min. There were no adverse effects on gas exchange or cardiovascular parameters until a flow rate of 3 l/min was used, when inadequate gas exchange occurred. Conclusions: Ti is inversely associated with the bias gas flow rate. Flow rates much lower than those used in many neonatal units seem to provide adequate ventilation. We suggest that the role of ventilator gas flow rates, which may potentially influence shear stress in ventilator-induced lung injury, merits further investigation.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 12, 2008
Accepted: October 08, 2008
Published online: May 27, 2009
Issue release date: November 2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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