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Table of Contents
Vol. 45, No. 6, 1999
Issue release date: November – December
Section title: Review
Gerontology 1999;45:301–306
(DOI:10.1159/000022109)

Influence of Age on Regeneration in the Peripheral Nervous System

Kerezoudi E.a · Thomas P.K.b
aPolyclinic, Hospital of Athens, Greece; bDepartment of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: November 03, 1999
Issue release date: November – December

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

Abstract

Studies on the influence of age on regeneration in the peripheral nervous system are reviewed. Observations in the human are limited, but clinical experience indicates that the efficiency of regeneration is less in later life. The results of experimental studies in animals, although sometimes variable, indicate a decline with age. This may be correlated with reduced axonal transport. At motor nerve terminals, the capacity to produce ultraterminal sprouting secondary to partial denervation is reduced, but not the capacity to eliminate terminal sprouts or reinnervation. Frequency and accuracy of reoccupation of the sites of motor nerve terminals are impaired. Nerve transection is more likely to result in loss of the parent neurons following nerve transection in young than in older animals. Chromatolysis is more intense and does not return to normal as rapidly in old animals, and the degree of retrograde axonal atrophy is less. This suggests a diminished dependence on peripheral growth factor support.

© 1999 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: November 03, 1999
Issue release date: November – December

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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