Both caffeine and theophyllme acting in subinhibitory concentrations inhibit the synthesis of peniciUinase in Staphylococcus aureus. Neither of these compounds inactivate the enzyme. Inhibition of peniciUinase synthesis is attributed to the lack of formation of peniciUinase rather than the elimination of the extrachromosomal plasmid.
B. G. Charles, B. Pharm., PhD, Pharmaceutics Research Laboratory, College of Pharmacy, University of Iowa, Iowa City, IA 52242 (USA)
Published online: August 05, 2009
Number of Print Pages : 6
Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)
Vol. 23, No. 6, Year 1977 (Cover Date: 1977)
Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009-3157 (Print), eISSN: 1421-9794 (Online)
For additional information: http://www.karger.com/CHE
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