were mated in culture vials containing Vinblastine, dissolved in distilled water, at concentrations of 0, 0.16, 0.31, 0.63, 1.25, and 2.5 μg/ml. Progeny were examined daily from the 10th through the 17th days. The frequency of teratogenic effects increased with the concentration. A distinct cephalo-caudal gradient of the ectodermal tissue was observed with cephalic anomalies predominating. Eyes, antennae, wings, halteres, head, and thorax showed notable anomalies.
Authors’ addresses: F.C. Clayton, M.S., Department of Zoology, Colorado State University, Fort Collins, CO 80521; R.T. Francoeur, Ph.D., Biology Dept. Fairleigh Dickinson University, Florham-Madison, NJ 07940 (USA)
Number of Print Pages : 5
Vol. 25, No. 2, Year 1971 (Cover Date: 1971)
Journal Editor: Markman M. (Houston, Tex.)
ISSN: NIL (Print), eISSN: NIL (Online)
For additional information: http://www.karger.com/OCL
Copyright / Drug Dosage
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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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