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Table of Contents
Vol. 28, No. 2, 2009
Issue release date: July 2009
Section title: Original Paper
Cerebrovasc Dis 2009;28:177–184
(DOI:10.1159/000226117)

Association of White-Matter Lesions with Brain Atrophy Markers: The Three-City Dijon MRI Study

Godin O.a, b · Maillard P.d–f · Crivello F.d–f · Alpérovitch A.a, b · Mazoyer B.c–g · Tzourio C.a, b · Dufouil C.a, b
aInserm U708 ‘Neuroepidemiology’, bUPMC University Paris 6, and cInstitut Universitaire de France, Paris, and dCNRS, CI-NAPS UMR6232, eCEA, DSV/I2BM/CI-NAPS, fUniversité de Caen Basse-Normande and gCentre Hospitalier et Universitaire de Caen, Caen, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 30, 2008
Accepted: March 27, 2009
Published online: June 25, 2009
Issue release date: July 2009

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: Brain atrophy and white-matter lesions (WML) are common features at cerebral MRI of both normal and demented elderly people. In a population-based study of 1,792 elderly subjects aged 65–80 years, free of dementia, who had a cerebral MRI at entry, we investigated the relationship between WML volume and brain atrophy markers estimated by hippocampal, gray matter (GM) and cerebrospinal fluid (CSF) volumes. Methods: An automated algorithm of detection and quantification of WML was developed, and voxel-based morphometry methods were used to estimate GM, CSF and hippocampal volumes. To evaluate the relation between those volumes and WML load, we used analysis of covariance and multiple linear regression models adjusting for potential confounders and total intracranial volumes. Results: Age was highly correlated with WML load and all brain atrophy markers. Total WML volume was negatively associated with both GM (β = –0.03, p < 0.0001) and hippocampal volumes (β = –0.75, p = 0.0009) and positively with CSF volumes (β = 0.008, p = 0.02) after controlling for sex, age, education level, hypertension and apolipoprotein E genotype. Evidence for a relationship between brain atrophy markers and WML was stronger for periventricular WML. We found that the relationship between WML and hippocampal volumes was independent of other brain tissue volumes. Conclusion: These results suggest that, in the brain of nondemented elderly subjects, degenerative processes and vascular changes co-occur and are related independently of vascular risk factors.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 30, 2008
Accepted: March 27, 2009
Published online: June 25, 2009
Issue release date: July 2009

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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