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Vol. 43, No. 5, 1986
Issue release date: 1986
Section title: Original Paper
Oncology 1986;43:283–287
(DOI:10.1159/000226383)

Analgetic Activity of Calcitonin in Patients with Painful Osteolytic Metastases of Breast Cancer

Results of a Controlled Randomized Study

Roth A. · Kolarić K.
Central Institute for Tumors and Allied Diseases, Zagreb, Yugoslavia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/23/2009
Issue release date: 1986

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

The analgesic effect of salmon calcitonin was tested by a double-blind clinical randomized controlled trial in 40 female patients with painful osteolytic metastases. Twenty patients were administered (daily) 100 IU of salmon calcitonin subcutaneously over 28 days, while the other 20 were administered identical ampoules containing 2 ml of physiological solution over the same period of time. The basic treatment (chemotherapy, hormone therapy) was not changed during the trial, and had to be stabilized for a minimum of 3 months prior to the trial. The effect of calcitonin was monitored with respect to daily analgesic consumption, duration of pain, patient’s functional capacity, patient’s own assessment of pain, and assessment of efficacy by the investigator. Statistically significant differences were established in terms of reduced analgesic consumption, shorter duration of pain and the patient’s subjective assessment of pain duration and intensity; the difference was not statistically significant with regard to patient’s functional capacity. The objective assessment of the analgesic effect of calcitonin by the investigator showed the drug to be extremely useful in 3 patients and moderately useful in 11 patients; 3 instances of ‘moderately useful’ were observed in the placebo group. No changes were observed in serum calcium levels; there were likewise no skeleton changes as established by X-rays and bone scintiscans before and at the end of treatment. The trial has shown calcitonin to produce a pronounced analgesic effect in breast cancer patients with painful osteolytic metastases.

© 1986 S. Karger AG, Basel


  

Author Contacts

Anton Roth, MD, PhD, Central Institute for Tumors and Allied Diseases, Ilica 197, YU–41000 Zagreb (Yugoslavia)

  

Article Information

Published online: June 23, 2009
Number of Print Pages : 5

  

Publication Details

Oncology (International Journal of Cancer Research and Treatment)

Vol. 43, No. 5, Year 1986 (Cover Date: 1986)

Journal Editor: Markman M. (Houston, Tex.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/23/2009
Issue release date: 1986

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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