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Vol. 49, No. 5, 1992
Issue release date: 1992
Section title: Original Paper
Oncology 1992;49:363–367
(DOI:10.1159/000227074)

Correlation of c-erbB-2 Protein Expression and Lymph Node Status in Early Gastric Cancer

Yonemura Y.a · Ninomiya I.a · Ohoyama S.a · Fushida S.a · Kimura H.a · Tsugawa K.a · Kamata T.a · Yamaguchi A.a · Miyazaki I.a · Endou Y.b · Tanaka M.b · Sasaki T.b
aSurgery II, School of Medicine, and bDepartment of Experimental Therapeutics and Biophysics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/26/2009
Issue release date: 1992

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

For the prediction of nodal status of early gastric cancer, sections of formalin-fixed, paraffin-embedded tissue from 220 early gastric cancers were analyzed immunohistochemically, using a polyclonal antibody against erbB-2 protein. The data of erbB-2 protein expression have been correlated with pathologic data, and a logistic regression analysis was made for the estimation of the significant factors responsible for lymph node metastasis. A pattern consistent with cell membrane staining was regarded as most specific for the erbB-2 expression. There were 22 (10%) cancers with evidence of erbB-2 protein expression. Positive staining was associated with only lymph node metastasis. The risk oflymph node metastasis was 3-fold greater in tumors having erbB-2 protein expression than in tumors without the expression. When the erbB-2 tissue status and clinicopathological parameters were entered into the logistic regression analysis, erbB-2 protein expression emerged as one of the independent significant factors for lymph node metastasis. These results indicate that early gastric cancer with erbB-2 protein expression may represent a potential risk of lymph node metastasis.

© 1992 S. Karger AG, Basel


  

Author Contacts

Dr. Yutaka Yonemura Surgery II, School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa (Japan)

  

Article Information

Published online: June 26, 2009
Number of Print Pages : 5

  

Publication Details

Oncology (International Journal of Cancer Research and Treatment)

Vol. 49, No. 5, Year 1992 (Cover Date: 1992)

Journal Editor: Markman M. (Houston, Tex.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/26/2009
Issue release date: 1992

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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