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Table of Contents
Vol. 53, No. 3, 1996
Issue release date: 1996
Section title: Clinical Study
Oncology 1996;53:192–197
(DOI:10.1159/000227559)

Overexpression of c-ErbB-2 Protein in Gastric Cancer by Immunohistochemical Stain

Lee H.R.a,b · Kim J.-H.a,b · Uhm H.D.a · Ahn J.B.a,b · Rha S.Y.a,b · Cho J.Y.a,b · Lee J.I.a,b · Lee K.H.a,b · Chung H.C.a,b · Roh J.K.a,b · Min J.S.c · Lee K.S.c · Shin D.H.c · Kim B.S.d · Kim B.S.d · Hong S.W.e · Choi J.-H.f
aYonsei Cancer Center, bDepartment of Internal Medicine, cDepartment of General Surgery, dDepartment of Pathology, Yonsei University College of Medicine, eDepartment of Pathology, Seoul Christian General Hospital, and fDepartment of Internal Medicine, Ewha Woman’s University, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Published online: June 30, 2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Published online: June 30, 2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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