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Vol. 113, No. 1, 2009
Issue release date: August 2009
Section title: Original Paper
Nephron Clin Pract 2009;113:c38–c45
(DOI:10.1159/000228074)

Increased Iron Requirement in Hemodialysis Patients on Antiplatelet Agents or Warfarin

Flint S. · Taylor E. · Beavis J. · Becker G.J. · Pedagogos E.
Department of Nephrology, Royal Melbourne Hospital, Melbourne, Vic., Australia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/25/2008
Accepted: 12/1/2008
Published online: 7/10/2009
Issue release date: August 2009

Number of Print Pages: 1
Number of Figures: 2
Number of Tables: 5

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC

Abstract

Background/Aims: Many hemodialysis patients receive antiplatelet therapy or warfarin; however, little is known about the effect of this on iron requirements. Given the association of antiplatelet therapy with bleeding we hypothesized that there should be a greater need for iron in such patients, which we tested in this study. Methods: Retrospective 1-year cohort study of 205 chronic hemodialysis patients. The primary outcome variable was total iron dose, which was analyzed according to antiplatelet/warfarin use. Data were also collected on potential confounders, allowing for both unadjusted and adjusted (multiple regression) analysis. Results: 97/205 patients received antiplatelet/warfarin therapy. This group was older, with a higher incidence of macrovascular disease and diabetes and a higher median C-reactive protein (6.0 vs. 3.75 mg/l). Overall, median iron requirement was 1,300 mg/year. In a multiple regression analysis, antiplatelet/warfarin use was associated with an additional iron requirement of 703 mg (95% confidence interval 188–1,220 mg), with the strongest effect observed in patients with normal inflammatory markers. Conclusion: We found a high requirement for iron in patients receiving antiplatelet agents/warfarin. We argue that the most likely mechanism for this association is chronic, low-grade blood loss, although further study is required before causality can be established.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/25/2008
Accepted: 12/1/2008
Published online: 7/10/2009
Issue release date: August 2009

Number of Print Pages: 1
Number of Figures: 2
Number of Tables: 5

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


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