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Table of Contents
Vol. 27, No. 6, 2009
Issue release date: July 2009
Section title: Original Research Article
Free Access
Dement Geriatr Cogn Disord 2009;27:564–571

Cognitive and Noncognitive Neurological Features of Young-Onset Dementia

Kelley B.J. · Boeve B.F. · Josephs K.A.
Department of Neurology, Mayo Clinic, Rochester, Minn., USA
email Corresponding Author

Brendan J. Kelley, MD

Department of Neurology, University of Cincinnati

260 Stetson Street, Suite 2300

Cincinnati, OH 45267 (USA)

Tel. +1 513 558 5501, Fax +1 513 558 4305, E-Mail kelleyb3@uc.edu

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Background: The rarity of young-onset dementia (YOD), the broad differential diagnosis and unusual clinical presentations present unique challenges to correctly recognize the condition and establish an accurate diagnosis. Limited data exist regarding clinical features associated with dementia prior to the age of 45. Methods: We retrospectively assessed cognitive and noncognitive neurological characteristics of 235 patients who presented for evaluation of YOD to investigate the clinical characteristics of YOD compared to later-onset dementias and to identify clinical features associated with specific etiologies that may aid in the evaluation of YOD. Results: Multiple cognitive domains were affected in most patients, and no significant differences in affected domains existed between groups. Early psychiatric and behavioral features occurred at very high frequencies. Nearly 80% of this YOD cohort had additional noncognitive symptoms or signs as a feature of their disease. Chorea was strongly associated with Huntington disease. Parkinsonism was not seen in patients having an autoimmune/inflammatory etiology. Conclusions: The rarity of YOD and the high frequency of early psychiatric features led to frequent misdiagnosis early in the clinical course. The high frequency of noncognitive symptoms and signs may aid clinicians in distinguishing patients requiring a more extensive evaluation for YOD.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: March 16, 2009
Published online: July 11, 2009
Issue release date: July 2009

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 5

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

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