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Table of Contents
Vol. 28, No. 1, 2009
Issue release date: August 2009
Section title: Original Research Article
Dement Geriatr Cogn Disord 2009;28:1–5
(DOI:10.1159/000228544)

Evaluation of Cerebellar Asymmetry in Alzheimer’s Disease: A Stereological Study

Kusbeci O.Y.a · Bas O.f · Gocmen-Mas N.b · Karabekir H.S.c · Yucel A.d · Ertekin T.e · Yazici A.C.g
Departments of aNeurology, bAnatomy, cNeurosurgery, and dRadiology, Faculty of Medicine, and eVocational School of Health Services, Afyon Kocatepe University, Afyonkarahisar, fDepartment of Anatomy, School of Medicine, Rize University, Rize, and gDepartment of Biostatistics, School of Medicine, Baskent University, Ankara, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: May 25, 2009
Published online: July 14, 2009
Issue release date: August 2009

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Objectives: Alzheimer’s disease (AD) is the most common cause of dementia and, as previous studies have indicated, degenerative changes in the cerebellum occur in AD. It is well known that the cerebellum does not have a symmetric morphology and some pathological disorders, such as schizophrenia, epilepsy, autism and alcoholism, can cause asymmetrical changes in the cerebellum. In this study, we aimed to evaluate whether or not patients with AD show cerebellar asymmetry. We also intended to depict the probable volumetric asymmetry by using a stereological technique. Materials and Methods: The study evaluated the volu- metric measurements of each cerebellar hemisphere by applying a stereological method to MR images. This age- and gender-matched study was composed of 15 patients with probable AD and 14 healthy subjects (controls). MR images were analyzed by using the point-counting approach, holding to Cavalieri’s principle. Results: Although there was significant cerebellar atrophy in AD patients, the study showed no statistically significant cerebellar asymmetry according to age and gender, both in the study and control groups (p > 0.05). Conclusions: There was no difference in cerebellar asymmetry associated with age and gender between the AD patients and control subjects. The stereological evaluation of cerebellar asymmetry correlating with gender is of importance to both clinicians and anatomists. The technique is simple, inexpensive, reliable and unbiased.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: May 25, 2009
Published online: July 14, 2009
Issue release date: August 2009

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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