In this short report, we address some practical problems in performing likelihood-based allelic association analysis of case-control data. Model-free statistics are proposed and their properties assessed by simulation, and procedures based on permutation tests are described for marker-marker as well as marker-disease associations. A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed.
© 1999 S. Karger AG, Basel
Jing Hua Zhao
Department of Psychological Medicine
Institute of Psychiatry, De Crespigny Park
London SE5 8AF (UK)
Tel. +44 171 919 25 24, Fax +44 171 701 90 44, E-Mail email@example.com
Received: Received: December 17, 1998
Revision received: February 15, 1999
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 19
Human Heredity (International Journal of Human and Medical Genetics)
Founded 1950 as Acta Genetica et Statistica Medica by Gunnar Dahlberg; Continued by M. Hauge (1965–1983)
Vol. 50, No. 2, Year 2000 (Cover Date: March-April 2000 (Released November 1999))
Journal Editor: J. Ott, New York, N.Y.
ISSN: 0001–5652 (print), 1423–0062 (Online)
For additional information: http://www.karger.ch/journals/hhe
Article / Publication Details
Published online: 11/24/1999
Issue release date: March–April 2000 (November 1999)
Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: http://www.karger.com/HHE
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