Model-Free Analysis and Permutation Tests for Allelic AssociationsZhao J.H. · Curtis D. · Sham P.C.
aDepartment of Psychological Medicine, Institute of Psychiatry, and bJoint Academic Department of Psychological Medicine, St. Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK
In this short report, we address some practical problems in performing likelihood-based allelic association analysis of case-control data. Model-free statistics are proposed and their properties assessed by simulation, and procedures based on permutation tests are described for marker-marker as well as marker-disease associations. A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed.
Jing Hua Zhao
Department of Psychological Medicine
Institute of Psychiatry, De Crespigny Park
London SE5 8AF (UK)
Tel. +44 171 919 25 24, Fax +44 171 701 90 44, E-Mail firstname.lastname@example.org
Received: Received: December 17, 1998
Revision received: February 15, 1999
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 19
Human Heredity (International Journal of Human and Medical Genetics)
Founded 1950 as Acta Genetica et Statistica Medica by Gunnar Dahlberg; Continued by M. Hauge (1965–1983)
Vol. 50, No. 2, Year 2000 (Cover Date: March-April 2000 (Released November 1999))
Journal Editor: J. Ott, New York, N.Y.
ISSN: 0001–5652 (print), 1423–0062 (Online)
For additional information: http://www.karger.ch/journals/hhe