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Vol. 28, No. 3, 2009
Issue release date: August 2009
Section title: Original Paper
Cerebrovasc Dis 2009;28:306–313
(DOI:10.1159/000229017)

T2*-Weighted MRI versus Oxygen Extraction Fraction PET in Acute Stroke

Donswijk M.L.a · Jones P.S.a · Guadagno J.V.a · Carpenter T.A.b · Moustafa R.R.a · Fryer T.D.b · Aigbirhio F.I.b · Warburton E.A.c · Baron J.C.a
aStroke Research Group and bWolfson Brain Imaging Centre, Department of Clinical Neurosciences and cStroke Unit, Department of Medicine, University of Cambridge, Cambridge, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/24/2008
Accepted: 5/12/2009
Published online: 7/21/2009
Issue release date: August 2009

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: Mapping high oxygen extraction fraction (OEF) in acute stroke is of considerable interest to depict the at-risk tissue. Being sensitive to deoxyhemoglobin, T2*-weighted MRI has been suggested as a potential marker of high OEF. Methods: We compared T2*-weighted images from pre-contrast arrival perfusion scans against quantitative positron emission tomography in 5 patients studied 7–21 h after onset of carotid territory stroke. OEF and T2* signal were obtained in the voxels with significantly high OEF. Results: All patients showed increased OEF. No significant relationship between OEF and T2*-weighted signal was found either within or between subjects. Conclusion: We found no indication that T2*-weighted MRI in the way implemented in this investigation was sensitive to high OEF in acute stroke.

© 2009 S. Karger AG, Basel


  

Author Contacts

Prof. J.-C. Baron
Department of Clinical Neurosciences, University of Cambridge
R3, Box 83, Addenbrooke’s Hospital
Cambridge CB2 2QQ (UK)
Tel. +44 1223 217 806, Fax +44 1223 217 909, E-Mail jcb54@cam.ac.uk

  

Article Information

Received: December 24, 2008
Accepted: May 12, 2009
Published online: July 21, 2009
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 3, Number of References : 19

  

Publication Details

Cerebrovascular Diseases

Vol. 28, No. 3, Year 2009 (Cover Date: August 2009)

Journal Editor: Hennerici M.G. (Mannheim)
ISSN: 1015-9770 (Print), eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/24/2008
Accepted: 5/12/2009
Published online: 7/21/2009
Issue release date: August 2009

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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