Objectives: We sought to investigate the association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation and the risk of coronary artery disease (CAD), myocardial infarction (MI) and venous thrombosis (VT) in a Chinese population in Taiwan. Methods: The subjects included 218 CAD patients, 107 VT patients, and their age- and sex-matched controls. DNA was extracted from the blood and genotypes were determined by polymerase chain reaction, restriction mapping with HinfI and gel electrophoresis. Results: The distribution of MTHFR genotypes was similar in the CAD cases and controls; the genotype TT was present in 6.0% of CAD patients, as compared to 6.9% of CAD control subjects (p = 0.165; odds ratio = 0.86; 95% confidence interval = 0.40–1.85). The frequency of the T allele was also similar in CAD cases and controls (25.5% vs. 24.8%; p = 0.788). There was no significant association between TT homozygosity and the risk of MI. The genotype distributions and the frequency of the T allele were also similar in VT cases and controls. Conclusions: Our data suggest that there is no association between the C677T mutation of the human MTHFR gene and the risk of CAD or VT among Chinese in Taiwan.
© 2000 S. Karger AG, Basel
Dr. Yu-Lin Ko
The First Cardiovascular Division, Chang-Gung Memorial Hospital
199 Tung Hwa North Road
Taipei (Taiwan, Republic of China)
Tel. +886 3 328 1200 (ext 8162), Fax +886 3 327 1192, E-Mail firstname.lastname@example.org
Received: Received: August 10, 1999
Accepted: October 18, 1999
Revision received: October 14, 1999
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 5, Number of References : 28
Human Heredity (International Journal of Human and Medical Genetics)
Founded 1950 as Acta Genetica et Statistica Medica by Gunnar Dahlberg; Continued by M. Hauge (1965–1983)
Vol. 51, No. 1-2, Year 2001 (Cover Date: Released October 2000)
Journal Editor: J. Ott, New York, N.Y.
ISSN: 0001–5652 (print), 1423–0062 (Online)
For additional information: http://www.karger.ch/journals/hhe
Article / Publication Details
Published online: 10/30/2000
Issue release date: October 2000
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 5
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: http://www.karger.com/HHE
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