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Table of Contents
Vol. 97, No. 1, 2010
Issue release date: December 2009
Section title: Original Paper
Neonatology 2010;97:56–60
(DOI:10.1159/000231517)

Gastric Emptying of Preterm Neonates Receiving Domperidone

Gounaris A.a · Costalos C.c · Varchalama E.b · Kokori F.b · Grivea I.N.d · Konstantinidi K.a · Syrogiannopoulos G.A.d
aNICU and bDepartment of Ultrasonography, General Hospital ‘Agios Panteleimon’, Nikea, cNICU, General Hospital ‘Alexandra’, Athens, and dDepartment of Pediatrics, University General Hospital, University of Thessaly, School of Medicine, Larissa, Greece

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 07, 2008
Accepted: December 15, 2008
Published online: July 31, 2009
Issue release date: December 2009

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Objectives: Immature gut motility in very low birth weight infants causes feeding intolerance. We evaluated the effect of domperidone, a prokinetic agent, on gastric emptying in very low birth weight infants. Methods: The study was conducted in a crossover design. Gastric emptying was assessed ultrasonographically by measuring the time it took the antral cross sectional area of the stomach to reach half of the value of the 1st measurement on 2 occasions: (1) upon administration of domperidone (0.3 mg/kg/8 h p.o.) for at least 2 days and (2) while patients received an equal quantity of sterile water. 11 infants were randomly assigned to receive domperidone before the 1st measurement and the remaining afterwards. There was a 3–5 day interval between the 2 measurements. At the time when both measurements were performed, every neonate had been receiving the same quantity and quality of milk. 12 infants were formula-fed while 10 were fed their own mother’s supplemented milk. Results: 22 infants with a mean (SD) birth weight of 1,377 g (319) and a mean (SD) gestational age of 30.2 weeks (2.1) were studied. The mean (SD) antral cross sectional area half-value time (in minutes) was 47.6 (23.9) in the domperidone group and 68.2 (25.5) in the control group (p = 0.008). There was no significant difference between formula-fed neonates and neonates fed their own mother’s milk in either group. Conclusions: Domperidone significantly reduces gastric emptying in preterm neonates, and this may account for its effect in cases of disturbances related to gut motility.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 07, 2008
Accepted: December 15, 2008
Published online: July 31, 2009
Issue release date: December 2009

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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