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Table of Contents
Vol. 17, No. 4, 2009
Issue release date: September 2009
Section title: Paper
Neurosignals 2009;17:234–241

Signals Involved in Neural Differentiation of Human Embryonic Stem Cells

Denham M.a · Dottori M.a, b
aCentre for Neuroscience, and bDepartment of Pharmacology, The University of Melbourne, Parkville, Vic., Australia
email Corresponding Author

Mirella Dottori, PhD

Stem Cell Laboratory, Centre for Neuroscience and Department of Pharmacology

Level 7, West Wing, Medical Building, The University of Melbourne

Parkville, Vic. 3010 (Australia)

Tel. +61 3 8344 3988, Fax +61 3 9349 4432, E-Mail mdottori@unimelb.edu.au

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Neural differentiation from embryonic stem cells involves progressive stages of neural induction, expansion and maintenance of neural stem/progenitor cells, and differentiation to neurons and glia. Our understanding of the signals involved in each of these processes is primarily based on our knowledge of neural development during embryogenesis. This review will focus on the signalling pathways that have been identified to play a role in neural differentiation of human embryonic stem cells (hESCs), including their induction to neuroectoderm, maintenance and expansion of hESC-derived neurospheres, differentiation to neurons and specification to specific neuronal lineages. Understanding the signals involved in each of these stages is important for optimising methods to derive specific cell types for transplantation therapies, as well as for providing insight into the mechanisms of human neurogenesis.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 27, 2009
Accepted: June 18, 2009
Published online: September 30, 2009
Issue release date: September 2009

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG

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