III. Mediators of Allergic Reactions. Endogenous and Exogenous Stimulating or Suppressor Substances
The quantities and the avidities of antibodies against birch pollen and, in some sera, timothy pollen were studied in atopic patients during the course of hyposensitization therapy with aqueous or Allyral allergen extracts. The ammonium-sulphate precipitation (ASP) technique was used to determine the allergen-binding capacity of the sera before and after absorption with anti-human IgE antibodies conjugated to Sepharose. Furthermore, IgE antibodies were determined with the radioallergosorbent test (RAST). IgE as well as non-IgE antibody titres increased after initiation of immunotherapy but after 2–3 years of treatment the IgE antibodies decreased, according to RAST results. No consistent pattern of increase or decrease of antibody titres was seen during the pollen seasons. However, a decrease of RAST values as well as of non-IgE titres determined with the ASP technique was found between the post-season sera from the first year of therapy and the pre-season sera the following year in respect of birch pollen allergen. No significant changes of antibody avidities were seen, nor could any significant correlations be found between the patients symptom scores during the birch pollen season and the antibody titres or avidities. The findings were similar for timothy pollen. It is concluded that the improvement of reagin-mediated symptoms found during immunotherapy is not caused by changes in the amounts or avidities of the specific antibodies detectable in the serum with the methods mployed, but other factors have to be sought.
Correspondence to: Dr. Staffan Ahlstedt, Research and Development Lab., Astra Läkemedel AB, S-151 85 Södertälje (Sweden)
Published online: July 24, 2009
Number of Print Pages : 12
International Archives of Allergy and Immunology
Vol. 55, No. 1-6, Year 1977 (Cover Date: 1977)
Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA
Copyright / Drug Dosage
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.