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Vol. 65, No. 3, 1981
Issue release date: 1981
Section title: Original Paper
Int. Archs Allergy appl. Immun 1981;65:323–338
(DOI:10.1159/000232772)

Orally Induced Tolerance

Definition at the Cellular Level

Titus R.G. · Chiller J.M.
National Jewish Hospital and Research Center, Denver, Colo., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/28/1980
Published online: 7/30/2009
Issue release date: 1981

Number of Print Pages: 16
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Several elements of the phenomenon of oral tolerance were examined. It was shown that whereas intragastric (i.g.) exposure of mice to the T-dependent antigens oval-bumin (OVA), bovine serum albumin, and human gamma globulin severely compromised the ability to respond to a subsequent challenge with the homologous antigen, i.g. treatment with T-independent antigens such as dinitrophenylated Ficoll, polyvinylpyrrolidone and bacterial lipopolysaccharide (LPS) did not induce anergy. Furthermore, mice parenterally primed to OVA were not only refractory to the induction of oral tolerance with OVA, but displayed an anamnestic response following i.g. treatment with the antigen. In a final line of investigation, it was shown that whereas mice administered OVA orally lost specific T cell functions such as the ability to (a) provide helper activity; (b) proliferate in response to antigen, and (c) mediate delayed-type hypersensitivity, such animals possessed OVA-specific functional B cells as evidenced by the ability to respond to OVA when the antigen was administered either linked to a recognizable carrier or in conjunction with LPS.

© 1981 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Dr. Richard G. Titus, National Jewish Hospital and Research Center, 3800 East Colfax Avenue, Denver, CO 80206 (USA)

  

Article Information

Received: August 28, 1980
Published online: July 30, 2009
Number of Print Pages : 16

  

Publication Details

International Archives of Allergy and Immunology

Vol. 65, No. 3, Year 1981 (Cover Date: 1981)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/28/1980
Published online: 7/30/2009
Issue release date: 1981

Number of Print Pages: 16
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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